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High Expression of Casein Kinase 2 Alpha Is Responsible for Enhanced Phosphorylation of DNA Mismatch Repair Protein MLH1 and Increased Tumor Mutation Rates in Colorectal Cancer

SIMPLE SUMMARY: Colorectal cancer (CRC) is associated with DNA mismatch repair (MMR) deficiency. The serine/threonine casein kinase 2 alpha (CK2α) is able to phosphorylate and inhibit MMR protein MLH1 in vitro. This study aimed to analyze the relevance of CK2α for MLH1 phosphorylation in vivo. Aroun...

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Detalles Bibliográficos
Autores principales:	Ulreich, Katharina, Firnau, May-Britt, Tagscherer, Nina, Beyer, Sandra, Ackermann, Anne, Plotz, Guido, Brieger, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946085/ https://www.ncbi.nlm.nih.gov/pubmed/35326704 http://dx.doi.org/10.3390/cancers14061553

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