In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D(3), and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network

SIMPLE SUMMARY: Failure of chemotherapy is common during the treatment of colon cancer, and there is a compelling need to develop alternative therapeutic approaches against this common malignancy. Metformin, which is an oral hypoglycaemic agent used for treating diabetes mellitus, and vitamin D have...

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Detalles Bibliográficos
Autores principales: Almaimani, Riyad Adnan, Aslam, Akhmed, Ahmad, Jawwad, El-Readi, Mahmoud Zaki, El-Boshy, Mohamed E., Abdelghany, Abdelghany H., Idris, Shakir, Alhadrami, Mai, Althubiti, Mohammad, Almasmoum, Hussain A., Ghaith, Mazen M., Elzubeir, Mohamed E., Eid, Safaa Yehia, Refaat, Bassem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946120/
https://www.ncbi.nlm.nih.gov/pubmed/35326689
http://dx.doi.org/10.3390/cancers14061538

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