Nature-Inspired O-Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress

Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing a concomitant anti-oxidant activity through dual-a...

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Detalles Bibliográficos
Autores principales: Ciccone, Lidia, Petrarolo, Giovanni, Barsuglia, Francesca, Fruchart-Gaillard, Carole, Cassar Lajeunesse, Evelyne, Adewumi, Adeniyi T., Soliman, Mahmoud E. S., La Motta, Concettina, Orlandini, Elisabetta, Nencetti, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946157/
https://www.ncbi.nlm.nih.gov/pubmed/35327641
http://dx.doi.org/10.3390/biom12030448

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