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Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases

SIMPLE SUMMARY: The aim of the present retrospective study was to develop a new scoring system for prognosis of patients undergoing surgery for breast cancer brain metastasis. Our institutional cohort (n = 95) was analyzed with regard to independent predictors of short (<6 months) and long (≥3 ye...

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Autores principales: Michel, Anna, Darkwah Oppong, Marvin, Rauschenbach, Laurèl, Dinger, Thiemo Florin, Barthel, Lennart, Pierscianek, Daniela, Wrede, Karsten H., Hense, Jörg, Pöttgen, Christoph, Junker, Andreas, Schmidt, Teresa, Iannaccone, Antonella, Kimmig, Rainer, Sure, Ulrich, Jabbarli, Ramazan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946189/
https://www.ncbi.nlm.nih.gov/pubmed/35326590
http://dx.doi.org/10.3390/cancers14061437
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author Michel, Anna
Darkwah Oppong, Marvin
Rauschenbach, Laurèl
Dinger, Thiemo Florin
Barthel, Lennart
Pierscianek, Daniela
Wrede, Karsten H.
Hense, Jörg
Pöttgen, Christoph
Junker, Andreas
Schmidt, Teresa
Iannaccone, Antonella
Kimmig, Rainer
Sure, Ulrich
Jabbarli, Ramazan
author_facet Michel, Anna
Darkwah Oppong, Marvin
Rauschenbach, Laurèl
Dinger, Thiemo Florin
Barthel, Lennart
Pierscianek, Daniela
Wrede, Karsten H.
Hense, Jörg
Pöttgen, Christoph
Junker, Andreas
Schmidt, Teresa
Iannaccone, Antonella
Kimmig, Rainer
Sure, Ulrich
Jabbarli, Ramazan
author_sort Michel, Anna
collection PubMed
description SIMPLE SUMMARY: The aim of the present retrospective study was to develop a new scoring system for prognosis of patients undergoing surgery for breast cancer brain metastasis. Our institutional cohort (n = 95) was analyzed with regard to independent predictors of short (<6 months) and long (≥3 years) survival. Breast-preserving surgery, presence of multiple brain metastases, and age ≥ 65 years at brain cancer diagnosis were associated with short survival. In turn, positive HER2 receptor status in brain metastasis, time interval ≥ 3 years between breast cancer and brain metastasis diagnosis and KPS ≥ 90% were the long survival predictors. The scores based on the above-mentioned independent predictors showed good diagnostic accuracy for the prediction of short (AUC = 0.773) and long (AUC = 0.775) survival. After external validation, the presented scores might become useful tools to support the interdisciplinary decision for the selection of treatment strategy in individuals with breast cancer brain metastases. ABSTRACT: Background: Brain metastases requiring surgical treatment determine the prognosis of patients with breast cancer. We aimed to develop the scores for the prediction of short (<6 months) and long (≥3 years) survival after BCBM surgery. Methods: Female patients with BCBM surgery between 2008 and 2019 were included. The new scores were constructed upon independent predictors for short and long postoperative survival. Results: In the final cohort (n = 95), 18 (18.9%) and 22 (23.2%) patients experienced short and long postoperative survival, respectively. Breast-preserving surgery, presence of multiple brain metastases and age ≥ 65 years at breast cancer diagnosis were identified as independent predictors of short postoperative survival. In turn, positive HER2 receptor status in brain metastases, time interval ≥ 3 years between breast cancer and brain metastases diagnosis and KPS ≥ 90% independently predicted long survival. The appropriate short and long survival scores showed higher diagnostic accuracy for the prediction of short (AUC = 0.773) and long (AUC = 0.775) survival than the breast Graded Prognostic Assessment score (AUC = 0.498/0.615). A cumulative survival score (total score) showed significant association with overall survival (p = 0.001). Conclusion: We identified predictors independently impacting the prognosis after BCBM surgery. After external validation, the presented scores might become useful tools for the selection of proper candidates for BCBM surgery.
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spelling pubmed-89461892022-03-25 Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases Michel, Anna Darkwah Oppong, Marvin Rauschenbach, Laurèl Dinger, Thiemo Florin Barthel, Lennart Pierscianek, Daniela Wrede, Karsten H. Hense, Jörg Pöttgen, Christoph Junker, Andreas Schmidt, Teresa Iannaccone, Antonella Kimmig, Rainer Sure, Ulrich Jabbarli, Ramazan Cancers (Basel) Article SIMPLE SUMMARY: The aim of the present retrospective study was to develop a new scoring system for prognosis of patients undergoing surgery for breast cancer brain metastasis. Our institutional cohort (n = 95) was analyzed with regard to independent predictors of short (<6 months) and long (≥3 years) survival. Breast-preserving surgery, presence of multiple brain metastases, and age ≥ 65 years at brain cancer diagnosis were associated with short survival. In turn, positive HER2 receptor status in brain metastasis, time interval ≥ 3 years between breast cancer and brain metastasis diagnosis and KPS ≥ 90% were the long survival predictors. The scores based on the above-mentioned independent predictors showed good diagnostic accuracy for the prediction of short (AUC = 0.773) and long (AUC = 0.775) survival. After external validation, the presented scores might become useful tools to support the interdisciplinary decision for the selection of treatment strategy in individuals with breast cancer brain metastases. ABSTRACT: Background: Brain metastases requiring surgical treatment determine the prognosis of patients with breast cancer. We aimed to develop the scores for the prediction of short (<6 months) and long (≥3 years) survival after BCBM surgery. Methods: Female patients with BCBM surgery between 2008 and 2019 were included. The new scores were constructed upon independent predictors for short and long postoperative survival. Results: In the final cohort (n = 95), 18 (18.9%) and 22 (23.2%) patients experienced short and long postoperative survival, respectively. Breast-preserving surgery, presence of multiple brain metastases and age ≥ 65 years at breast cancer diagnosis were identified as independent predictors of short postoperative survival. In turn, positive HER2 receptor status in brain metastases, time interval ≥ 3 years between breast cancer and brain metastases diagnosis and KPS ≥ 90% independently predicted long survival. The appropriate short and long survival scores showed higher diagnostic accuracy for the prediction of short (AUC = 0.773) and long (AUC = 0.775) survival than the breast Graded Prognostic Assessment score (AUC = 0.498/0.615). A cumulative survival score (total score) showed significant association with overall survival (p = 0.001). Conclusion: We identified predictors independently impacting the prognosis after BCBM surgery. After external validation, the presented scores might become useful tools for the selection of proper candidates for BCBM surgery. MDPI 2022-03-10 /pmc/articles/PMC8946189/ /pubmed/35326590 http://dx.doi.org/10.3390/cancers14061437 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michel, Anna
Darkwah Oppong, Marvin
Rauschenbach, Laurèl
Dinger, Thiemo Florin
Barthel, Lennart
Pierscianek, Daniela
Wrede, Karsten H.
Hense, Jörg
Pöttgen, Christoph
Junker, Andreas
Schmidt, Teresa
Iannaccone, Antonella
Kimmig, Rainer
Sure, Ulrich
Jabbarli, Ramazan
Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases
title Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases
title_full Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases
title_fullStr Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases
title_full_unstemmed Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases
title_short Prediction of Short and Long Survival after Surgery for Breast Cancer Brain Metastases
title_sort prediction of short and long survival after surgery for breast cancer brain metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946189/
https://www.ncbi.nlm.nih.gov/pubmed/35326590
http://dx.doi.org/10.3390/cancers14061437
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