Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8(+) T Cells in Immunotherapy-Resistant and Metastatic Cancers

SIMPLE SUMMARY: Some important signaling proteins that control how cells grow and behave not only act in the cytoplasm but also in the nucleus, where they tether to chromatin. This is especially true for protein kinase C (PKC)-θ, which acts in the nucleus to mediate cancer hallmarks that drive metas...

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Detalles Bibliográficos
Autores principales: Dunn, Jenny, McCuaig, Robert D., Tan, Abel H. Y., Tu, Wen Juan, Wu, Fan, Wagstaff, Kylie M., Zafar, Anjum, Ali, Sayed, Diwakar, Himanshu, Dahlstrom, Jane E., Bean, Elaine G., Forwood, Jade K., Tsimbalyuk, Sofiya, Cross, Emily M., Hardy, Kristine, Bain, Amanda L., Ahern, Elizabeth, Dolcetti, Riccardo, Mazzieri, Roberta, Yip, Desmond, Eastgate, Melissa, Malik, Laeeq, Milburn, Peter, Jans, David A., Rao, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946217/
https://www.ncbi.nlm.nih.gov/pubmed/35326747
http://dx.doi.org/10.3390/cancers14061596

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