Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?

Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown that inhibition of immunoglobulin G binding o...

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Detalles Bibliográficos
Autores principales: Zakrzewicz, Anna, Würth, Celina, Beckert, Benedikt, Feldhoff, Simon, Vanderheyden, Katrien, Foss, Stian, Andersen, Jan Terje, de Haard, Hans, Verheesen, Peter, Bobkov, Vladimir, Tikkanen, Ritva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946243/
https://www.ncbi.nlm.nih.gov/pubmed/35326398
http://dx.doi.org/10.3390/cells11060942

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