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Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia

Some symptoms of schizophrenia might be present before full-blown psychosis, so white matter changes must be studied both in individuals with emerging psychosis and chronic schizophrenia. A total of 86 patients—12 ultra-high risk of psychosis (UHR), 20 first episode psychosis (FEP), 54 chronic schiz...

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Autores principales: Waszczuk, Katarzyna, Tyburski, Ernest, Rek-Owodziń, Katarzyna, Plichta, Piotr, Rudkowski, Krzysztof, Podwalski, Piotr, Bielecki, Maksymilian, Mak, Monika, Bober, Adrianna, Misiak, Błażej, Sagan, Leszek, Michalczyk, Anna, Kucharska-Mazur, Jolanta, Samochowiec, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946295/
https://www.ncbi.nlm.nih.gov/pubmed/35326310
http://dx.doi.org/10.3390/brainsci12030354
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author Waszczuk, Katarzyna
Tyburski, Ernest
Rek-Owodziń, Katarzyna
Plichta, Piotr
Rudkowski, Krzysztof
Podwalski, Piotr
Bielecki, Maksymilian
Mak, Monika
Bober, Adrianna
Misiak, Błażej
Sagan, Leszek
Michalczyk, Anna
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
author_facet Waszczuk, Katarzyna
Tyburski, Ernest
Rek-Owodziń, Katarzyna
Plichta, Piotr
Rudkowski, Krzysztof
Podwalski, Piotr
Bielecki, Maksymilian
Mak, Monika
Bober, Adrianna
Misiak, Błażej
Sagan, Leszek
Michalczyk, Anna
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
author_sort Waszczuk, Katarzyna
collection PubMed
description Some symptoms of schizophrenia might be present before full-blown psychosis, so white matter changes must be studied both in individuals with emerging psychosis and chronic schizophrenia. A total of 86 patients—12 ultra-high risk of psychosis (UHR), 20 first episode psychosis (FEP), 54 chronic schizophrenia (CS), and 33 healthy controls (HC)—underwent psychiatric examination and diffusion tensor imaging (DTI) in a 3-Tesla MRI scanner. We assessed fractional anisotropy (FA) and mean diffusivity (MD) of the superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILS). We found that CS patients had lower FA than FEP patients (p = 0.025) and HC (p = 0.088), and higher MD than HC (p = 0.037) in the right SLF. In the CS group, we found positive correlations of MD in both right ILF (rho = 0.39, p < 0.05) and SLF (rho = 0.43, p < 0.01) with disorganization symptoms, as well as negative correlation of FA in the right ILF with disorganization symptoms (rho = −0.43, p < 0.05). Among UHR individuals, we found significant negative correlations between MD in the left ILF and negative (r = −0.74, p < 0.05) and general symptoms (r = −0.77, p < 0.05). However promising, these findings should be treated as preliminary, and further research must verify whether they can be treated as potential biomarkers of psychosis.
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spelling pubmed-89462952022-03-25 Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia Waszczuk, Katarzyna Tyburski, Ernest Rek-Owodziń, Katarzyna Plichta, Piotr Rudkowski, Krzysztof Podwalski, Piotr Bielecki, Maksymilian Mak, Monika Bober, Adrianna Misiak, Błażej Sagan, Leszek Michalczyk, Anna Kucharska-Mazur, Jolanta Samochowiec, Jerzy Brain Sci Article Some symptoms of schizophrenia might be present before full-blown psychosis, so white matter changes must be studied both in individuals with emerging psychosis and chronic schizophrenia. A total of 86 patients—12 ultra-high risk of psychosis (UHR), 20 first episode psychosis (FEP), 54 chronic schizophrenia (CS), and 33 healthy controls (HC)—underwent psychiatric examination and diffusion tensor imaging (DTI) in a 3-Tesla MRI scanner. We assessed fractional anisotropy (FA) and mean diffusivity (MD) of the superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILS). We found that CS patients had lower FA than FEP patients (p = 0.025) and HC (p = 0.088), and higher MD than HC (p = 0.037) in the right SLF. In the CS group, we found positive correlations of MD in both right ILF (rho = 0.39, p < 0.05) and SLF (rho = 0.43, p < 0.01) with disorganization symptoms, as well as negative correlation of FA in the right ILF with disorganization symptoms (rho = −0.43, p < 0.05). Among UHR individuals, we found significant negative correlations between MD in the left ILF and negative (r = −0.74, p < 0.05) and general symptoms (r = −0.77, p < 0.05). However promising, these findings should be treated as preliminary, and further research must verify whether they can be treated as potential biomarkers of psychosis. MDPI 2022-03-07 /pmc/articles/PMC8946295/ /pubmed/35326310 http://dx.doi.org/10.3390/brainsci12030354 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Waszczuk, Katarzyna
Tyburski, Ernest
Rek-Owodziń, Katarzyna
Plichta, Piotr
Rudkowski, Krzysztof
Podwalski, Piotr
Bielecki, Maksymilian
Mak, Monika
Bober, Adrianna
Misiak, Błażej
Sagan, Leszek
Michalczyk, Anna
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia
title Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia
title_full Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia
title_fullStr Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia
title_full_unstemmed Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia
title_short Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia
title_sort relationship between white matter alterations and pathophysiological symptoms in patients with ultra-high risk of psychosis, first-episode, and chronic schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946295/
https://www.ncbi.nlm.nih.gov/pubmed/35326310
http://dx.doi.org/10.3390/brainsci12030354
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