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Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala
In the monkey brain, the precentral gyrus and ventral intraparietal area are two interconnected brain regions that form a system for detecting and responding to events in nearby “peripersonal” space (PPS), with threat detection as one of its major functions. Behavioral studies point toward a similar...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946485/ https://www.ncbi.nlm.nih.gov/pubmed/35326349 http://dx.doi.org/10.3390/brainsci12030391 |
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author | de Borst, Aline W. de Gelder, Beatrice |
author_facet | de Borst, Aline W. de Gelder, Beatrice |
author_sort | de Borst, Aline W. |
collection | PubMed |
description | In the monkey brain, the precentral gyrus and ventral intraparietal area are two interconnected brain regions that form a system for detecting and responding to events in nearby “peripersonal” space (PPS), with threat detection as one of its major functions. Behavioral studies point toward a similar defensive function of PPS in humans. Here, our aim was to find support for this hypothesis by investigating if homolog regions in the human brain respond more strongly to approaching threatening stimuli. During fMRI scanning, naturalistic social stimuli were presented in a 3D virtual environment. Our results showed that the ventral premotor cortex and intraparietal sulcus responded more strongly to threatening stimuli entering PPS. Moreover, we found evidence for the involvement of the amygdala and anterior insula in processing threats. We propose that the defensive function of PPS may be supported by a subcortical circuit that sends information about the relevance of the stimulus to the premotor cortex and intraparietal sulcus, where action preparation is facilitated when necessary. |
format | Online Article Text |
id | pubmed-8946485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89464852022-03-25 Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala de Borst, Aline W. de Gelder, Beatrice Brain Sci Article In the monkey brain, the precentral gyrus and ventral intraparietal area are two interconnected brain regions that form a system for detecting and responding to events in nearby “peripersonal” space (PPS), with threat detection as one of its major functions. Behavioral studies point toward a similar defensive function of PPS in humans. Here, our aim was to find support for this hypothesis by investigating if homolog regions in the human brain respond more strongly to approaching threatening stimuli. During fMRI scanning, naturalistic social stimuli were presented in a 3D virtual environment. Our results showed that the ventral premotor cortex and intraparietal sulcus responded more strongly to threatening stimuli entering PPS. Moreover, we found evidence for the involvement of the amygdala and anterior insula in processing threats. We propose that the defensive function of PPS may be supported by a subcortical circuit that sends information about the relevance of the stimulus to the premotor cortex and intraparietal sulcus, where action preparation is facilitated when necessary. MDPI 2022-03-15 /pmc/articles/PMC8946485/ /pubmed/35326349 http://dx.doi.org/10.3390/brainsci12030391 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Borst, Aline W. de Gelder, Beatrice Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala |
title | Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala |
title_full | Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala |
title_fullStr | Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala |
title_full_unstemmed | Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala |
title_short | Threat Detection in Nearby Space Mobilizes Human Ventral Premotor Cortex, Intraparietal Sulcus, and Amygdala |
title_sort | threat detection in nearby space mobilizes human ventral premotor cortex, intraparietal sulcus, and amygdala |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946485/ https://www.ncbi.nlm.nih.gov/pubmed/35326349 http://dx.doi.org/10.3390/brainsci12030391 |
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