CDK6 Degradation Is Counteracted by p16(INK4A) and p18(INK4C) in AML

SIMPLE SUMMARY: CDK4/6 kinase inhibitors show promising results in various subtypes of AML, which has been primarily assigned to the inhibition of CDK6. To bypass therapeutic resistances and tackle the kinase-dependent, as well as kinase-independent, functions of CDK6, new CDK6 degraders have been d...

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Detalles Bibliográficos
Autores principales: Schmalzbauer, Belinda S., Thondanpallil, Teresemary, Heller, Gerwin, Schirripa, Alessia, Sperl, Clio-Melina, Mayer, Isabella M., Knab, Vanessa M., Nebenfuehr, Sofie, Zojer, Markus, Mueller, André C., Fontaine, Frédéric, Klampfl, Thorsten, Sexl, Veronika, Kollmann, Karoline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946512/
https://www.ncbi.nlm.nih.gov/pubmed/35326705
http://dx.doi.org/10.3390/cancers14061554

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