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Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a highly regulated multi-step process for the formation of new blood vessels that contribute to tumor proliferation. EVs...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946542/ https://www.ncbi.nlm.nih.gov/pubmed/35326397 http://dx.doi.org/10.3390/cells11060947 |
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author | Hu, Miao Li, Juan Liu, Chen-Guang Goh, Robby Miguel W. J. Yu, Fenggang Ma, Zhaowu Wang, Lingzhi |
author_facet | Hu, Miao Li, Juan Liu, Chen-Guang Goh, Robby Miguel W. J. Yu, Fenggang Ma, Zhaowu Wang, Lingzhi |
author_sort | Hu, Miao |
collection | PubMed |
description | Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a highly regulated multi-step process for the formation of new blood vessels that contribute to tumor proliferation. EVs induce malignant transformation of distinct cells by transferring DNAs, proteins, lipids, and RNAs, including noncoding RNAs (ncRNAs). However, the functional relevance of EV-derived ncRNAs in tumor angiogenesis remains to be elucidated. In this review, we summarized current research progress on the biological functions and underlying mechanisms of EV-derived ncRNAs in tumor angiogenesis in various cancers. In addition, we comprehensively discussed the potential applications of EV-derived ncRNAs as cancer biomarkers and novel therapeutic targets to tailor anti-angiogenic therapy. |
format | Online Article Text |
id | pubmed-8946542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89465422022-03-25 Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance Hu, Miao Li, Juan Liu, Chen-Guang Goh, Robby Miguel W. J. Yu, Fenggang Ma, Zhaowu Wang, Lingzhi Cells Review Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a highly regulated multi-step process for the formation of new blood vessels that contribute to tumor proliferation. EVs induce malignant transformation of distinct cells by transferring DNAs, proteins, lipids, and RNAs, including noncoding RNAs (ncRNAs). However, the functional relevance of EV-derived ncRNAs in tumor angiogenesis remains to be elucidated. In this review, we summarized current research progress on the biological functions and underlying mechanisms of EV-derived ncRNAs in tumor angiogenesis in various cancers. In addition, we comprehensively discussed the potential applications of EV-derived ncRNAs as cancer biomarkers and novel therapeutic targets to tailor anti-angiogenic therapy. MDPI 2022-03-10 /pmc/articles/PMC8946542/ /pubmed/35326397 http://dx.doi.org/10.3390/cells11060947 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hu, Miao Li, Juan Liu, Chen-Guang Goh, Robby Miguel W. J. Yu, Fenggang Ma, Zhaowu Wang, Lingzhi Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance |
title | Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance |
title_full | Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance |
title_fullStr | Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance |
title_full_unstemmed | Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance |
title_short | Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance |
title_sort | noncoding rnas of extracellular vesicles in tumor angiogenesis: from biological functions to clinical significance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946542/ https://www.ncbi.nlm.nih.gov/pubmed/35326397 http://dx.doi.org/10.3390/cells11060947 |
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