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Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance

Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a highly regulated multi-step process for the formation of new blood vessels that contribute to tumor proliferation. EVs...

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Detalles Bibliográficos
Autores principales: Hu, Miao, Li, Juan, Liu, Chen-Guang, Goh, Robby Miguel W. J., Yu, Fenggang, Ma, Zhaowu, Wang, Lingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946542/
https://www.ncbi.nlm.nih.gov/pubmed/35326397
http://dx.doi.org/10.3390/cells11060947
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author Hu, Miao
Li, Juan
Liu, Chen-Guang
Goh, Robby Miguel W. J.
Yu, Fenggang
Ma, Zhaowu
Wang, Lingzhi
author_facet Hu, Miao
Li, Juan
Liu, Chen-Guang
Goh, Robby Miguel W. J.
Yu, Fenggang
Ma, Zhaowu
Wang, Lingzhi
author_sort Hu, Miao
collection PubMed
description Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a highly regulated multi-step process for the formation of new blood vessels that contribute to tumor proliferation. EVs induce malignant transformation of distinct cells by transferring DNAs, proteins, lipids, and RNAs, including noncoding RNAs (ncRNAs). However, the functional relevance of EV-derived ncRNAs in tumor angiogenesis remains to be elucidated. In this review, we summarized current research progress on the biological functions and underlying mechanisms of EV-derived ncRNAs in tumor angiogenesis in various cancers. In addition, we comprehensively discussed the potential applications of EV-derived ncRNAs as cancer biomarkers and novel therapeutic targets to tailor anti-angiogenic therapy.
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spelling pubmed-89465422022-03-25 Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance Hu, Miao Li, Juan Liu, Chen-Guang Goh, Robby Miguel W. J. Yu, Fenggang Ma, Zhaowu Wang, Lingzhi Cells Review Extracellular vesicles (EVs) act as multifunctional regulators of intercellular communication and are involved in diverse tumor phenotypes, including tumor angiogenesis, which is a highly regulated multi-step process for the formation of new blood vessels that contribute to tumor proliferation. EVs induce malignant transformation of distinct cells by transferring DNAs, proteins, lipids, and RNAs, including noncoding RNAs (ncRNAs). However, the functional relevance of EV-derived ncRNAs in tumor angiogenesis remains to be elucidated. In this review, we summarized current research progress on the biological functions and underlying mechanisms of EV-derived ncRNAs in tumor angiogenesis in various cancers. In addition, we comprehensively discussed the potential applications of EV-derived ncRNAs as cancer biomarkers and novel therapeutic targets to tailor anti-angiogenic therapy. MDPI 2022-03-10 /pmc/articles/PMC8946542/ /pubmed/35326397 http://dx.doi.org/10.3390/cells11060947 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Miao
Li, Juan
Liu, Chen-Guang
Goh, Robby Miguel W. J.
Yu, Fenggang
Ma, Zhaowu
Wang, Lingzhi
Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
title Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
title_full Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
title_fullStr Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
title_full_unstemmed Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
title_short Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
title_sort noncoding rnas of extracellular vesicles in tumor angiogenesis: from biological functions to clinical significance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946542/
https://www.ncbi.nlm.nih.gov/pubmed/35326397
http://dx.doi.org/10.3390/cells11060947
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