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COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
Background: With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination. Through this systematic review, we aim to discern these CNS and PNS manifestations followin...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946610/ https://www.ncbi.nlm.nih.gov/pubmed/35326363 http://dx.doi.org/10.3390/brainsci12030407 |
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author | Sriwastava, Shitiz Sharma, Kanika Khalid, Syed Hassan Bhansali, Sakhi Shrestha, Ashish K. Elkhooly, Mahmoud Srivastava, Samiksha Khan, Erum Jaiswal, Shruti Wen, Sijin |
author_facet | Sriwastava, Shitiz Sharma, Kanika Khalid, Syed Hassan Bhansali, Sakhi Shrestha, Ashish K. Elkhooly, Mahmoud Srivastava, Samiksha Khan, Erum Jaiswal, Shruti Wen, Sijin |
author_sort | Sriwastava, Shitiz |
collection | PubMed |
description | Background: With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination. Through this systematic review, we aim to discern these CNS and PNS manifestations following the COVID-19 vaccine to help produce methods to mitigate them. Methods: We conducted a thorough literature search of Google Scholar and PubMed from 1 December 2020 until 10 October 2021 and included all the case studies of COVID-19 vaccine-associated neurological side effects. The literature search and data analysis were performed by two independent reviewers according to prespecified inclusion and exclusion criteria using PRISMA. Results: The most common CNS manifestation was CVST (14.47%), found in females (64%) younger than 50 years (71%) after the first AstraZeneca dose (93%). Others included CNS demyelinating disorders (TM, ADEM, MS, NMOSD) (9.30%), encephalopathy/encephalitis (3.10%), and others (4.13%). The most common PNS manifestation was GBS (14.67%) found in males (71%) older than 50 years (79%), followed by Bell’s palsy (5.24%) and others (2.10%). Most occurred with the AstraZeneca (28.55%), Pfizer-BioNTech (9.18%), and Moderna (8.16%) vaccines. Nine (64%) out of the 14 patients with CVST died. However, most cases overall (42 out of 51) were non-fatal (82%). Conclusion: Several CNS and PNS adverse events have occurred post-COVID-19 vaccination, including CVST, GBS, and TM. High vigilance with early identification and treatment leads to better outcomes. Further studies with non-vaccinated controls might help in understanding the pathophysiologic mechanisms of these neurological manifestations following COVID-19 vaccination. |
format | Online Article Text |
id | pubmed-8946610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89466102022-03-25 COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series Sriwastava, Shitiz Sharma, Kanika Khalid, Syed Hassan Bhansali, Sakhi Shrestha, Ashish K. Elkhooly, Mahmoud Srivastava, Samiksha Khan, Erum Jaiswal, Shruti Wen, Sijin Brain Sci Review Background: With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination. Through this systematic review, we aim to discern these CNS and PNS manifestations following the COVID-19 vaccine to help produce methods to mitigate them. Methods: We conducted a thorough literature search of Google Scholar and PubMed from 1 December 2020 until 10 October 2021 and included all the case studies of COVID-19 vaccine-associated neurological side effects. The literature search and data analysis were performed by two independent reviewers according to prespecified inclusion and exclusion criteria using PRISMA. Results: The most common CNS manifestation was CVST (14.47%), found in females (64%) younger than 50 years (71%) after the first AstraZeneca dose (93%). Others included CNS demyelinating disorders (TM, ADEM, MS, NMOSD) (9.30%), encephalopathy/encephalitis (3.10%), and others (4.13%). The most common PNS manifestation was GBS (14.67%) found in males (71%) older than 50 years (79%), followed by Bell’s palsy (5.24%) and others (2.10%). Most occurred with the AstraZeneca (28.55%), Pfizer-BioNTech (9.18%), and Moderna (8.16%) vaccines. Nine (64%) out of the 14 patients with CVST died. However, most cases overall (42 out of 51) were non-fatal (82%). Conclusion: Several CNS and PNS adverse events have occurred post-COVID-19 vaccination, including CVST, GBS, and TM. High vigilance with early identification and treatment leads to better outcomes. Further studies with non-vaccinated controls might help in understanding the pathophysiologic mechanisms of these neurological manifestations following COVID-19 vaccination. MDPI 2022-03-18 /pmc/articles/PMC8946610/ /pubmed/35326363 http://dx.doi.org/10.3390/brainsci12030407 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sriwastava, Shitiz Sharma, Kanika Khalid, Syed Hassan Bhansali, Sakhi Shrestha, Ashish K. Elkhooly, Mahmoud Srivastava, Samiksha Khan, Erum Jaiswal, Shruti Wen, Sijin COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series |
title | COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series |
title_full | COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series |
title_fullStr | COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series |
title_full_unstemmed | COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series |
title_short | COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series |
title_sort | covid-19 vaccination and neurological manifestations: a review of case reports and case series |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946610/ https://www.ncbi.nlm.nih.gov/pubmed/35326363 http://dx.doi.org/10.3390/brainsci12030407 |
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