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COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series

Background: With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination. Through this systematic review, we aim to discern these CNS and PNS manifestations followin...

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Autores principales: Sriwastava, Shitiz, Sharma, Kanika, Khalid, Syed Hassan, Bhansali, Sakhi, Shrestha, Ashish K., Elkhooly, Mahmoud, Srivastava, Samiksha, Khan, Erum, Jaiswal, Shruti, Wen, Sijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946610/
https://www.ncbi.nlm.nih.gov/pubmed/35326363
http://dx.doi.org/10.3390/brainsci12030407
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author Sriwastava, Shitiz
Sharma, Kanika
Khalid, Syed Hassan
Bhansali, Sakhi
Shrestha, Ashish K.
Elkhooly, Mahmoud
Srivastava, Samiksha
Khan, Erum
Jaiswal, Shruti
Wen, Sijin
author_facet Sriwastava, Shitiz
Sharma, Kanika
Khalid, Syed Hassan
Bhansali, Sakhi
Shrestha, Ashish K.
Elkhooly, Mahmoud
Srivastava, Samiksha
Khan, Erum
Jaiswal, Shruti
Wen, Sijin
author_sort Sriwastava, Shitiz
collection PubMed
description Background: With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination. Through this systematic review, we aim to discern these CNS and PNS manifestations following the COVID-19 vaccine to help produce methods to mitigate them. Methods: We conducted a thorough literature search of Google Scholar and PubMed from 1 December 2020 until 10 October 2021 and included all the case studies of COVID-19 vaccine-associated neurological side effects. The literature search and data analysis were performed by two independent reviewers according to prespecified inclusion and exclusion criteria using PRISMA. Results: The most common CNS manifestation was CVST (14.47%), found in females (64%) younger than 50 years (71%) after the first AstraZeneca dose (93%). Others included CNS demyelinating disorders (TM, ADEM, MS, NMOSD) (9.30%), encephalopathy/encephalitis (3.10%), and others (4.13%). The most common PNS manifestation was GBS (14.67%) found in males (71%) older than 50 years (79%), followed by Bell’s palsy (5.24%) and others (2.10%). Most occurred with the AstraZeneca (28.55%), Pfizer-BioNTech (9.18%), and Moderna (8.16%) vaccines. Nine (64%) out of the 14 patients with CVST died. However, most cases overall (42 out of 51) were non-fatal (82%). Conclusion: Several CNS and PNS adverse events have occurred post-COVID-19 vaccination, including CVST, GBS, and TM. High vigilance with early identification and treatment leads to better outcomes. Further studies with non-vaccinated controls might help in understanding the pathophysiologic mechanisms of these neurological manifestations following COVID-19 vaccination.
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spelling pubmed-89466102022-03-25 COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series Sriwastava, Shitiz Sharma, Kanika Khalid, Syed Hassan Bhansali, Sakhi Shrestha, Ashish K. Elkhooly, Mahmoud Srivastava, Samiksha Khan, Erum Jaiswal, Shruti Wen, Sijin Brain Sci Review Background: With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination. Through this systematic review, we aim to discern these CNS and PNS manifestations following the COVID-19 vaccine to help produce methods to mitigate them. Methods: We conducted a thorough literature search of Google Scholar and PubMed from 1 December 2020 until 10 October 2021 and included all the case studies of COVID-19 vaccine-associated neurological side effects. The literature search and data analysis were performed by two independent reviewers according to prespecified inclusion and exclusion criteria using PRISMA. Results: The most common CNS manifestation was CVST (14.47%), found in females (64%) younger than 50 years (71%) after the first AstraZeneca dose (93%). Others included CNS demyelinating disorders (TM, ADEM, MS, NMOSD) (9.30%), encephalopathy/encephalitis (3.10%), and others (4.13%). The most common PNS manifestation was GBS (14.67%) found in males (71%) older than 50 years (79%), followed by Bell’s palsy (5.24%) and others (2.10%). Most occurred with the AstraZeneca (28.55%), Pfizer-BioNTech (9.18%), and Moderna (8.16%) vaccines. Nine (64%) out of the 14 patients with CVST died. However, most cases overall (42 out of 51) were non-fatal (82%). Conclusion: Several CNS and PNS adverse events have occurred post-COVID-19 vaccination, including CVST, GBS, and TM. High vigilance with early identification and treatment leads to better outcomes. Further studies with non-vaccinated controls might help in understanding the pathophysiologic mechanisms of these neurological manifestations following COVID-19 vaccination. MDPI 2022-03-18 /pmc/articles/PMC8946610/ /pubmed/35326363 http://dx.doi.org/10.3390/brainsci12030407 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sriwastava, Shitiz
Sharma, Kanika
Khalid, Syed Hassan
Bhansali, Sakhi
Shrestha, Ashish K.
Elkhooly, Mahmoud
Srivastava, Samiksha
Khan, Erum
Jaiswal, Shruti
Wen, Sijin
COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
title COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
title_full COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
title_fullStr COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
title_full_unstemmed COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
title_short COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series
title_sort covid-19 vaccination and neurological manifestations: a review of case reports and case series
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946610/
https://www.ncbi.nlm.nih.gov/pubmed/35326363
http://dx.doi.org/10.3390/brainsci12030407
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