Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial

SIMPLE SUMMARY: Primary cutaneous T-cell lymphomas (CTCLs) are a group of lymphomas that present in the skin without extracutaneous localizations at diagnosis. Recent studies in clinical and translational research augmented our understanding of the pathogenesis and pathophysiology of different subty...

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Detalles Bibliográficos
Autores principales: Wind, Selinde S., Jansen, Manon A. A., Rijsbergen, Melanie, van Esdonk, Michiel J., Ziagkos, Dimitrios, Cheng, Wing C., Niemeyer-van der Kolk, Tessa, Korsten, John, Gruszka, Agnieszka, Schmitz-Rohmer, Debora, Bonnel, David, Legouffe, Raphael, Barré, Florian, Bekkenk, Marcel W., de Haas, Ellen R. M., Quint, Koen D., Rolli, Melanie, Streefkerk, Henk Johan, Burggraaf, Jacobus, Vermeer, Maarten H., Rissmann, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946662/
https://www.ncbi.nlm.nih.gov/pubmed/35326659
http://dx.doi.org/10.3390/cancers14061510

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