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The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China

A total of 1155 partial pol gene sequences of human immunodeficiency virus (HIV)-1 CRF07_BC were sampled between 1997 and 2015, spanning 13 provinces in Mainland China and risk groups [heterosexual, injecting drug users (IDU), and men who have sex with men (MSM)] to investigate the evolution, adapta...

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Autores principales: Li, Xingguang, Li, Yanping, Liu, Haizhou, Trovão, Nídia S, Foley, Brian T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946679/
https://www.ncbi.nlm.nih.gov/pubmed/35350472
http://dx.doi.org/10.1093/ve/veac014
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author Li, Xingguang
Li, Yanping
Liu, Haizhou
Trovão, Nídia S
Foley, Brian T
author_facet Li, Xingguang
Li, Yanping
Liu, Haizhou
Trovão, Nídia S
Foley, Brian T
author_sort Li, Xingguang
collection PubMed
description A total of 1155 partial pol gene sequences of human immunodeficiency virus (HIV)-1 CRF07_BC were sampled between 1997 and 2015, spanning 13 provinces in Mainland China and risk groups [heterosexual, injecting drug users (IDU), and men who have sex with men (MSM)] to investigate the evolution, adaptation, spatiotemporal and risk group dynamics, migration patterns, and protein structure of HIV-1 CRF07_BC. Due to the unequal distribution of sequences across time, location, and risk group in the complete dataset (‘full1155’), subsampling methods were used. Maximum-likelihood and Bayesian phylogenetic analysis as well as discrete trait analysis of geographical location and risk group were carried out. To study mutations of a cluster of HIV-1 CRF07_BC (CRF07-1), we performed a comparative analysis of this cluster to the other CRF07_BC sequences (‘backbone_295’) and mapped the mutations observed in the respective protein structure. Our findings showed that HIV-1 CRF07_BC most likely originated among IDU in Yunnan Province between October 1992 to July 1993 [95 per cent hightest posterior density (HPD): May 1989–August 1995] and that IDU in Yunnan Province and MSM in Guangdong Province likely served as the viral sources during the early and more recent spread in Mainland China. We also revealed that HIV-1 CRF07-1 has been spreading for roughly 20 years and continues to cause local transmission in Mainland China and worldwide. Overall, our study sheds light on the dynamics of HIV-1 CRF07_BC distribution patterns in Mainland China. Our research may also be useful in formulating public health policies aimed at controlling acquired immune deficiency syndrome in Mainland China and globally.
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spelling pubmed-89466792022-03-28 The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China Li, Xingguang Li, Yanping Liu, Haizhou Trovão, Nídia S Foley, Brian T Virus Evol Research Article A total of 1155 partial pol gene sequences of human immunodeficiency virus (HIV)-1 CRF07_BC were sampled between 1997 and 2015, spanning 13 provinces in Mainland China and risk groups [heterosexual, injecting drug users (IDU), and men who have sex with men (MSM)] to investigate the evolution, adaptation, spatiotemporal and risk group dynamics, migration patterns, and protein structure of HIV-1 CRF07_BC. Due to the unequal distribution of sequences across time, location, and risk group in the complete dataset (‘full1155’), subsampling methods were used. Maximum-likelihood and Bayesian phylogenetic analysis as well as discrete trait analysis of geographical location and risk group were carried out. To study mutations of a cluster of HIV-1 CRF07_BC (CRF07-1), we performed a comparative analysis of this cluster to the other CRF07_BC sequences (‘backbone_295’) and mapped the mutations observed in the respective protein structure. Our findings showed that HIV-1 CRF07_BC most likely originated among IDU in Yunnan Province between October 1992 to July 1993 [95 per cent hightest posterior density (HPD): May 1989–August 1995] and that IDU in Yunnan Province and MSM in Guangdong Province likely served as the viral sources during the early and more recent spread in Mainland China. We also revealed that HIV-1 CRF07-1 has been spreading for roughly 20 years and continues to cause local transmission in Mainland China and worldwide. Overall, our study sheds light on the dynamics of HIV-1 CRF07_BC distribution patterns in Mainland China. Our research may also be useful in formulating public health policies aimed at controlling acquired immune deficiency syndrome in Mainland China and globally. Oxford University Press 2022-02-17 /pmc/articles/PMC8946679/ /pubmed/35350472 http://dx.doi.org/10.1093/ve/veac014 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research Article
Li, Xingguang
Li, Yanping
Liu, Haizhou
Trovão, Nídia S
Foley, Brian T
The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China
title The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China
title_full The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China
title_fullStr The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China
title_full_unstemmed The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China
title_short The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China
title_sort emergence and transmission dynamics of hiv-1 crf07_bc in mainland china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946679/
https://www.ncbi.nlm.nih.gov/pubmed/35350472
http://dx.doi.org/10.1093/ve/veac014
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