Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report

We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibilit...

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Detalles Bibliográficos
Autores principales: Holger, Dana J, Kunz Coyne, Ashlan J, Zhao, Jing J, Sandhu, Avnish, Salimnia, Hossein, Rybak, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Novel ID Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946682/
https://www.ncbi.nlm.nih.gov/pubmed/35350174
http://dx.doi.org/10.1093/ofid/ofac092
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author Holger, Dana J
Kunz Coyne, Ashlan J
Zhao, Jing J
Sandhu, Avnish
Salimnia, Hossein
Rybak, Michael J
author_facet Holger, Dana J
Kunz Coyne, Ashlan J
Zhao, Jing J
Sandhu, Avnish
Salimnia, Hossein
Rybak, Michael J
author_sort Holger, Dana J
collection PubMed
description We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.
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spelling pubmed-89466822022-03-28 Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report Holger, Dana J Kunz Coyne, Ashlan J Zhao, Jing J Sandhu, Avnish Salimnia, Hossein Rybak, Michael J Open Forum Infect Dis Novel ID Cases We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy. Oxford University Press 2022-03-05 /pmc/articles/PMC8946682/ /pubmed/35350174 http://dx.doi.org/10.1093/ofid/ofac092 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Novel ID Cases
Holger, Dana J
Kunz Coyne, Ashlan J
Zhao, Jing J
Sandhu, Avnish
Salimnia, Hossein
Rybak, Michael J
Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report
title Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report
title_full Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report
title_fullStr Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report
title_full_unstemmed Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report
title_short Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report
title_sort novel combination therapy for extensively drug-resistant acinetobacter baumannii necrotizing pneumonia complicated by empyema: a case report
topic Novel ID Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946682/
https://www.ncbi.nlm.nih.gov/pubmed/35350174
http://dx.doi.org/10.1093/ofid/ofac092
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