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Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients

Cue reactivity is often used to study alcohol cues brain responses. Standardized image sets are used, but the effect of viewing people interacting with the alcohol drink remains unclear, which is associated with the factors of alcohol cues that influence the degree of response to alcohol stimuli. Th...

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Autores principales: Alarefi, Abdulqawi, Wang, Xunshi, Tao, Rui, Rui, Qinqin, Gao, Guoqing, Wang, Ying, Pang, Liangjun, Liu, Chialun, Zhang, Xiaochu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946691/
https://www.ncbi.nlm.nih.gov/pubmed/35326264
http://dx.doi.org/10.3390/brainsci12030307
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author Alarefi, Abdulqawi
Wang, Xunshi
Tao, Rui
Rui, Qinqin
Gao, Guoqing
Wang, Ying
Pang, Liangjun
Liu, Chialun
Zhang, Xiaochu
author_facet Alarefi, Abdulqawi
Wang, Xunshi
Tao, Rui
Rui, Qinqin
Gao, Guoqing
Wang, Ying
Pang, Liangjun
Liu, Chialun
Zhang, Xiaochu
author_sort Alarefi, Abdulqawi
collection PubMed
description Cue reactivity is often used to study alcohol cues brain responses. Standardized image sets are used, but the effect of viewing people interacting with the alcohol drink remains unclear, which is associated with the factors of alcohol cues that influence the degree of response to alcohol stimuli. The present study used fMRI to investigate the reactivity of alcohol dependence (AD) inpatients to alcohol cues with or without human drinking behavior. Cues with a human interacting with a drink were hypothesized to increase sensorimotor activation. In total, 30 AD inpatients were asked to view pictures with a factorial design of beverage types (alcoholic vs. non-alcoholic beverages) and cue types (with or without drink action). Whole-brain analyses were performed. A correlation analysis was conducted to confirm whether the whole-brain analysis revealed cue-related brain activations correlated with problem drinking duration. The left lingual gyrus showed significant beverage types through cue type interaction, and the bilateral temporal cortex showed significant activation in response to alcohol cues depicting human drinking behavior. The right and left lingual gyrus regions and left temporal cortex were positively correlated with problem drinking duration. Sensorimotor activations in the temporal cortex may reflect self-referential and memory-based scene processing. Thus, our findings indicate these regions are associated with alcohol use and suggest them for cue exposure treatment of alcohol addiction.
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spelling pubmed-89466912022-03-25 Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients Alarefi, Abdulqawi Wang, Xunshi Tao, Rui Rui, Qinqin Gao, Guoqing Wang, Ying Pang, Liangjun Liu, Chialun Zhang, Xiaochu Brain Sci Article Cue reactivity is often used to study alcohol cues brain responses. Standardized image sets are used, but the effect of viewing people interacting with the alcohol drink remains unclear, which is associated with the factors of alcohol cues that influence the degree of response to alcohol stimuli. The present study used fMRI to investigate the reactivity of alcohol dependence (AD) inpatients to alcohol cues with or without human drinking behavior. Cues with a human interacting with a drink were hypothesized to increase sensorimotor activation. In total, 30 AD inpatients were asked to view pictures with a factorial design of beverage types (alcoholic vs. non-alcoholic beverages) and cue types (with or without drink action). Whole-brain analyses were performed. A correlation analysis was conducted to confirm whether the whole-brain analysis revealed cue-related brain activations correlated with problem drinking duration. The left lingual gyrus showed significant beverage types through cue type interaction, and the bilateral temporal cortex showed significant activation in response to alcohol cues depicting human drinking behavior. The right and left lingual gyrus regions and left temporal cortex were positively correlated with problem drinking duration. Sensorimotor activations in the temporal cortex may reflect self-referential and memory-based scene processing. Thus, our findings indicate these regions are associated with alcohol use and suggest them for cue exposure treatment of alcohol addiction. MDPI 2022-02-24 /pmc/articles/PMC8946691/ /pubmed/35326264 http://dx.doi.org/10.3390/brainsci12030307 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alarefi, Abdulqawi
Wang, Xunshi
Tao, Rui
Rui, Qinqin
Gao, Guoqing
Wang, Ying
Pang, Liangjun
Liu, Chialun
Zhang, Xiaochu
Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
title Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
title_full Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
title_fullStr Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
title_full_unstemmed Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
title_short Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients
title_sort depicting people in visual cues affects alcohol cue reactivity in male alcohol-dependent patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946691/
https://www.ncbi.nlm.nih.gov/pubmed/35326264
http://dx.doi.org/10.3390/brainsci12030307
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