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Polymerase Epsilon-Associated Ultramutagenesis in Cancer

SIMPLE SUMMARY: DNA polymerase epsilon is implicated to play a major role in DNA synthesis of the leading strand. In some cancer types, especially colorectal and endometrial cancers, polymerase epsilon is mutated at several hotspots, causing large amounts of mutations, termed ultramutation. The aim...

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Detalles Bibliográficos
Autores principales:	Xing, XuanXuan, Jin, Ning, Wang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946778/ https://www.ncbi.nlm.nih.gov/pubmed/35326618 http://dx.doi.org/10.3390/cancers14061467

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