Cargando…

Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice

SIMPLE SUMMARY: Colitis-associated cancer is a colorectal cancer entity with poor prognosis and limited therapeutic options typically occurring as long-term complications of inflammatory bowel diseases. Connective tissue cells such as cancer-associated fibroblasts are part of the tumor microenvironm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heichler, Christina, Schmied, Anabel, Enderle, Karin, Scheibe, Kristina, Murawska, Marta, Schmid, Benjamin, Waldner, Maximilian J., Neurath, Markus F., Neufert, Clemens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946800/ https://www.ncbi.nlm.nih.gov/pubmed/35326623 http://dx.doi.org/10.3390/cancers14061472

Ejemplares similares

Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging
por: Kreiss, Lucas, et al.
Publicado: (2022)

Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer
por: Foersch, Sebastian, et al.
Publicado: (2013)

In vivo multi spectral colonoscopy in mice
por: Hohmann, Martin, et al.
Publicado: (2022)

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
por: Waldner, Maximilian J., et al.
Publicado: (2010)

Mechanisms of Immune Signaling in Colitis-Associated Cancer
por: Waldner, Maximilian J., et al.
Publicado: (2014)

Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis
por: Lindemann, Aylin, et al.
Publicado: (2023)

Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103-Dependent T Cell Migration
por: Enderle, Karin, et al.
Publicado: (2021)

Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer
por: Zundler, Sebastian, et al.
Publicado: (2016)

Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner
por: Buchele, Vera, et al.
Publicado: (2021)

Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles
por: Fuchs, Friederike, et al.
Publicado: (2017)

Computer-aided detection of colorectal polyps using a newly generated deep convolutional neural network: from development to first clinical experience
por: Pfeifer, Lukas, et al.
Publicado: (2021)

Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)
por: STEINMANN, SARA, et al.
Publicado: (2015)

Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer
por: Waldner, Maximilian J., et al.
Publicado: (2022)

TGFβ and the Tumor Microenvironment in Colorectal Cancer
por: Waldner, Maximilian J., et al.
Publicado: (2023)

Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis
por: Leppkes, Moritz, et al.
Publicado: (2022)

Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis
por: Koop, Kristina, et al.
Publicado: (2023)

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
por: Pickert, Geethanjali, et al.
Publicado: (2009)

Interleukin-6 - A Key Regulator of Colorectal Cancer Development
por: Waldner, Maximilian J., et al.
Publicado: (2012)

CRISPR/Cas9 in Gastrointestinal Malignancies
por: Jefremow, André, et al.
Publicado: (2021)

Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease
por: Matthe, Diana M., et al.
Publicado: (2023)

Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis
por: Rath, Timo, et al.
Publicado: (2023)

T Cell Aging in Patients with Colorectal Cancer—What Do We Know So Far?
por: Thoma, Oana-Maria, et al.
Publicado: (2021)

Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment
por: Thoma, Oana-Maria, et al.
Publicado: (2021)

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease
por: Schmitt, Heike, et al.
Publicado: (2019)

Comparison of Hemospray(®) and Endoclot(™) for the treatment of gastrointestinal bleeding
por: Vitali, Francesco, et al.
Publicado: (2019)

Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial
por: Rath, Timo, et al.
Publicado: (2020)

Targeting mucosal healing in Crohn’s disease: what the clinician needs to know
por: Klenske, Entcho, et al.
Publicado: (2019)

The Ominous Ouzo Party – A Case Series of Four Patients with Accidental Alkali Ingestion
por: Vetter, Marcel, et al.
Publicado: (2021)

Transrectal Absorber Guide Raster‐Scanning Optoacoustic Mesoscopy for Label‐Free In Vivo Assessment of Colitis
por: Buehler, Adrian, et al.
Publicado: (2023)

Topical application of Chlorin e6-PVP (Ce6-PVP) for improved endoscopic detection of neoplastic lesions in a murine colitis-associated cancer model
por: Ganzleben, Ingo, et al.
Publicado: (2020)

Telomerase deficiency reflects age-associated changes in CD4+ T cells
por: Matthe, Diana M., et al.
Publicado: (2022)

Innovative Diagnostic Endoscopy in Inflammatory Bowel Diseases: From High-Definition to Molecular Endoscopy
por: Bojarski, Christian, et al.
Publicado: (2021)

STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs
por: Chiriac, Mircea T., et al.
Publicado: (2023)

Lack of Intestinal Epithelial Atg7 Affects Paneth Cell Granule Formation but Does Not Compromise Immune Homeostasis in the Gut
por: Wittkopf, Nadine, et al.
Publicado: (2012)

Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo()
por: Ganzleben, Ingo, et al.
Publicado: (2022)

Single-cell analysis reveals the COL11A1(+) fibroblasts are cancer-specific fibroblasts that promote tumor progression
por: Zhang, Jiayu, et al.
Publicado: (2023)

Fallbericht: Persistierendes Fieber nach SARS-CoV-2-Infektion
por: Kliem, T., et al.
Publicado: (2022)

H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts
por: Zhang, Ying, et al.
Publicado: (2021)

Su095 REAL-TIME DEFORMABILITY CYTOMETRY (RT-DC) REVEALS NOVEL CORRELATIONS BETWEEN INFLAMMATION AND MECHANICAL PROPERTIES OF NEUTROPHILS IN IBD PATIENTS
por: Ganzleben, Ingo, et al.
Publicado: (2021)

Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection
por: Schmalzl, Angelika, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mic64eveiovodnlk6qtfksi5i3