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Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway
Tissue-engineered vascular grafts (TEVGs) are a promising alternative to treat vascular disease under complex hemodynamic conditions. However, despite efforts from the tissue engineering and regenerative medicine fields, the interactions between the material and the biological and hemodynamic enviro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946846/ https://www.ncbi.nlm.nih.gov/pubmed/35326390 http://dx.doi.org/10.3390/cells11060939 |
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author | Rodriguez-Soto, Maria A. Riveros, Alejandra Suarez Vargas, Natalia Garcia-Brand, Andres J. Muñoz Camargo, Carolina Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. |
author_facet | Rodriguez-Soto, Maria A. Riveros, Alejandra Suarez Vargas, Natalia Garcia-Brand, Andres J. Muñoz Camargo, Carolina Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. |
author_sort | Rodriguez-Soto, Maria A. |
collection | PubMed |
description | Tissue-engineered vascular grafts (TEVGs) are a promising alternative to treat vascular disease under complex hemodynamic conditions. However, despite efforts from the tissue engineering and regenerative medicine fields, the interactions between the material and the biological and hemodynamic environment are still to be understood, and optimization of the rational design of vascular grafts is an open challenge. This is of special importance as TEVGs not only have to overcome the surgical requirements upon implantation, they also need to withhold the inflammatory response and sustain remodeling of the tissue. This work aims to analyze and evaluate the bio-molecular interactions and hemodynamic phenomena between blood components, cells and materials that have been reported to be related to the failure of the TEVGs during the regeneration process once the initial stages of preimplantation have been resolved, in order to tailor and refine the needed criteria for the optimal design of TEVGs. |
format | Online Article Text |
id | pubmed-8946846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89468462022-03-25 Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway Rodriguez-Soto, Maria A. Riveros, Alejandra Suarez Vargas, Natalia Garcia-Brand, Andres J. Muñoz Camargo, Carolina Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. Cells Review Tissue-engineered vascular grafts (TEVGs) are a promising alternative to treat vascular disease under complex hemodynamic conditions. However, despite efforts from the tissue engineering and regenerative medicine fields, the interactions between the material and the biological and hemodynamic environment are still to be understood, and optimization of the rational design of vascular grafts is an open challenge. This is of special importance as TEVGs not only have to overcome the surgical requirements upon implantation, they also need to withhold the inflammatory response and sustain remodeling of the tissue. This work aims to analyze and evaluate the bio-molecular interactions and hemodynamic phenomena between blood components, cells and materials that have been reported to be related to the failure of the TEVGs during the regeneration process once the initial stages of preimplantation have been resolved, in order to tailor and refine the needed criteria for the optimal design of TEVGs. MDPI 2022-03-10 /pmc/articles/PMC8946846/ /pubmed/35326390 http://dx.doi.org/10.3390/cells11060939 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodriguez-Soto, Maria A. Riveros, Alejandra Suarez Vargas, Natalia Garcia-Brand, Andres J. Muñoz Camargo, Carolina Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway |
title | Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway |
title_full | Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway |
title_fullStr | Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway |
title_full_unstemmed | Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway |
title_short | Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway |
title_sort | failure analysis of tevg’s ii: late failure and entering the regeneration pathway |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946846/ https://www.ncbi.nlm.nih.gov/pubmed/35326390 http://dx.doi.org/10.3390/cells11060939 |
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