The Heat Shock Protein 90 Inhibitor, AT13387, Protects the Alveolo-Capillary Barrier and Prevents HCl-Induced Chronic Lung Injury and Pulmonary Fibrosis

Hydrochloric acid (HCl) exposure causes asthma-like conditions, reactive airways dysfunction syndrome, and pulmonary fibrosis. Heat Shock Protein 90 (HSP90) is a molecular chaperone that regulates multiple cellular processes. HSP90 inhibitors are undergoing clinical trials for cancer and are also be...

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Detalles Bibliográficos
Autores principales: Colunga Biancatelli, Ruben M. L., Solopov, Pavel, Dimitropoulou, Christiana, Gregory, Betsy, Day, Tierney, Catravas, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946990/
https://www.ncbi.nlm.nih.gov/pubmed/35326496
http://dx.doi.org/10.3390/cells11061046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946990/
https://www.ncbi.nlm.nih.gov/pubmed/35326496
http://dx.doi.org/10.3390/cells11061046

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