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The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study

Background: We assessed the SARS-CoV-2 reinfection rate in a large patient cohort, and evaluated the effect of varying time intervals between two positive tests on assumed reinfection rates using viral load data. Methods: All positive SARS-CoV-2 samples collected between 1 March 2020 and 1 August 20...

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Autores principales: Euser, Sjoerd M., Weenink, Tieme, Prins, Jan M., Haverkort, Milly, Manders, Irene, van Lelyveld, Steven, Herpers, Bjorn L., Sinnige, Jan, Kalpoe, Jayant, Snijders, Dominic, Cohen Stuart, James, Slijkerman Megelink, Fred, Kapteijns, Erik, den Boer, Jeroen, Wagemakers, Alex, Souverein, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947046/
https://www.ncbi.nlm.nih.gov/pubmed/35328272
http://dx.doi.org/10.3390/diagnostics12030719
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author Euser, Sjoerd M.
Weenink, Tieme
Prins, Jan M.
Haverkort, Milly
Manders, Irene
van Lelyveld, Steven
Herpers, Bjorn L.
Sinnige, Jan
Kalpoe, Jayant
Snijders, Dominic
Cohen Stuart, James
Slijkerman Megelink, Fred
Kapteijns, Erik
den Boer, Jeroen
Wagemakers, Alex
Souverein, Dennis
author_facet Euser, Sjoerd M.
Weenink, Tieme
Prins, Jan M.
Haverkort, Milly
Manders, Irene
van Lelyveld, Steven
Herpers, Bjorn L.
Sinnige, Jan
Kalpoe, Jayant
Snijders, Dominic
Cohen Stuart, James
Slijkerman Megelink, Fred
Kapteijns, Erik
den Boer, Jeroen
Wagemakers, Alex
Souverein, Dennis
author_sort Euser, Sjoerd M.
collection PubMed
description Background: We assessed the SARS-CoV-2 reinfection rate in a large patient cohort, and evaluated the effect of varying time intervals between two positive tests on assumed reinfection rates using viral load data. Methods: All positive SARS-CoV-2 samples collected between 1 March 2020 and 1 August 2021 from a laboratory in the region Kennemerland, the Netherlands, were included. The reinfection rate was analyzed using different time intervals between two positive tests varying between 2 and 16 weeks. SARS-CoV-2 PCR crossing point (Cp) values were used to estimate viral loads. Results: In total, 679,513 samples were analyzed, of which 53,366 tests (7.9%) were SARS-CoV-2 positive. The number of reinfections varied between 260 (0.52%) for an interval of 2 weeks, 89 (0.19%) for 4 weeks, 52 (0.11%) for 8 weeks, and 37 (0.09%) for a minimum interval of 16 weeks between positive tests. The median Cp-value (IQR) in the second positive samples decreased when a longer interval was chosen, but stabilized from week 8 onwards. Conclusions: Although the calculated reinfection prevalence was relatively low (0.11% for the 8-week time interval), choosing a different minimum interval between two positive tests resulted in major differences in reinfection rates. As reinfection Cp-values stabilized after 8 weeks, we hypothesize this interval to best reflect novel infection rather than persistent shedding.
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spelling pubmed-89470462022-03-25 The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study Euser, Sjoerd M. Weenink, Tieme Prins, Jan M. Haverkort, Milly Manders, Irene van Lelyveld, Steven Herpers, Bjorn L. Sinnige, Jan Kalpoe, Jayant Snijders, Dominic Cohen Stuart, James Slijkerman Megelink, Fred Kapteijns, Erik den Boer, Jeroen Wagemakers, Alex Souverein, Dennis Diagnostics (Basel) Communication Background: We assessed the SARS-CoV-2 reinfection rate in a large patient cohort, and evaluated the effect of varying time intervals between two positive tests on assumed reinfection rates using viral load data. Methods: All positive SARS-CoV-2 samples collected between 1 March 2020 and 1 August 2021 from a laboratory in the region Kennemerland, the Netherlands, were included. The reinfection rate was analyzed using different time intervals between two positive tests varying between 2 and 16 weeks. SARS-CoV-2 PCR crossing point (Cp) values were used to estimate viral loads. Results: In total, 679,513 samples were analyzed, of which 53,366 tests (7.9%) were SARS-CoV-2 positive. The number of reinfections varied between 260 (0.52%) for an interval of 2 weeks, 89 (0.19%) for 4 weeks, 52 (0.11%) for 8 weeks, and 37 (0.09%) for a minimum interval of 16 weeks between positive tests. The median Cp-value (IQR) in the second positive samples decreased when a longer interval was chosen, but stabilized from week 8 onwards. Conclusions: Although the calculated reinfection prevalence was relatively low (0.11% for the 8-week time interval), choosing a different minimum interval between two positive tests resulted in major differences in reinfection rates. As reinfection Cp-values stabilized after 8 weeks, we hypothesize this interval to best reflect novel infection rather than persistent shedding. MDPI 2022-03-15 /pmc/articles/PMC8947046/ /pubmed/35328272 http://dx.doi.org/10.3390/diagnostics12030719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Euser, Sjoerd M.
Weenink, Tieme
Prins, Jan M.
Haverkort, Milly
Manders, Irene
van Lelyveld, Steven
Herpers, Bjorn L.
Sinnige, Jan
Kalpoe, Jayant
Snijders, Dominic
Cohen Stuart, James
Slijkerman Megelink, Fred
Kapteijns, Erik
den Boer, Jeroen
Wagemakers, Alex
Souverein, Dennis
The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
title The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
title_full The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
title_fullStr The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
title_full_unstemmed The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
title_short The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
title_sort effect of varying interval definitions on the prevalence of sars-cov-2 reinfections: a retrospective cross-sectional cohort study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947046/
https://www.ncbi.nlm.nih.gov/pubmed/35328272
http://dx.doi.org/10.3390/diagnostics12030719
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