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The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study
Background: We assessed the SARS-CoV-2 reinfection rate in a large patient cohort, and evaluated the effect of varying time intervals between two positive tests on assumed reinfection rates using viral load data. Methods: All positive SARS-CoV-2 samples collected between 1 March 2020 and 1 August 20...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947046/ https://www.ncbi.nlm.nih.gov/pubmed/35328272 http://dx.doi.org/10.3390/diagnostics12030719 |
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author | Euser, Sjoerd M. Weenink, Tieme Prins, Jan M. Haverkort, Milly Manders, Irene van Lelyveld, Steven Herpers, Bjorn L. Sinnige, Jan Kalpoe, Jayant Snijders, Dominic Cohen Stuart, James Slijkerman Megelink, Fred Kapteijns, Erik den Boer, Jeroen Wagemakers, Alex Souverein, Dennis |
author_facet | Euser, Sjoerd M. Weenink, Tieme Prins, Jan M. Haverkort, Milly Manders, Irene van Lelyveld, Steven Herpers, Bjorn L. Sinnige, Jan Kalpoe, Jayant Snijders, Dominic Cohen Stuart, James Slijkerman Megelink, Fred Kapteijns, Erik den Boer, Jeroen Wagemakers, Alex Souverein, Dennis |
author_sort | Euser, Sjoerd M. |
collection | PubMed |
description | Background: We assessed the SARS-CoV-2 reinfection rate in a large patient cohort, and evaluated the effect of varying time intervals between two positive tests on assumed reinfection rates using viral load data. Methods: All positive SARS-CoV-2 samples collected between 1 March 2020 and 1 August 2021 from a laboratory in the region Kennemerland, the Netherlands, were included. The reinfection rate was analyzed using different time intervals between two positive tests varying between 2 and 16 weeks. SARS-CoV-2 PCR crossing point (Cp) values were used to estimate viral loads. Results: In total, 679,513 samples were analyzed, of which 53,366 tests (7.9%) were SARS-CoV-2 positive. The number of reinfections varied between 260 (0.52%) for an interval of 2 weeks, 89 (0.19%) for 4 weeks, 52 (0.11%) for 8 weeks, and 37 (0.09%) for a minimum interval of 16 weeks between positive tests. The median Cp-value (IQR) in the second positive samples decreased when a longer interval was chosen, but stabilized from week 8 onwards. Conclusions: Although the calculated reinfection prevalence was relatively low (0.11% for the 8-week time interval), choosing a different minimum interval between two positive tests resulted in major differences in reinfection rates. As reinfection Cp-values stabilized after 8 weeks, we hypothesize this interval to best reflect novel infection rather than persistent shedding. |
format | Online Article Text |
id | pubmed-8947046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89470462022-03-25 The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study Euser, Sjoerd M. Weenink, Tieme Prins, Jan M. Haverkort, Milly Manders, Irene van Lelyveld, Steven Herpers, Bjorn L. Sinnige, Jan Kalpoe, Jayant Snijders, Dominic Cohen Stuart, James Slijkerman Megelink, Fred Kapteijns, Erik den Boer, Jeroen Wagemakers, Alex Souverein, Dennis Diagnostics (Basel) Communication Background: We assessed the SARS-CoV-2 reinfection rate in a large patient cohort, and evaluated the effect of varying time intervals between two positive tests on assumed reinfection rates using viral load data. Methods: All positive SARS-CoV-2 samples collected between 1 March 2020 and 1 August 2021 from a laboratory in the region Kennemerland, the Netherlands, were included. The reinfection rate was analyzed using different time intervals between two positive tests varying between 2 and 16 weeks. SARS-CoV-2 PCR crossing point (Cp) values were used to estimate viral loads. Results: In total, 679,513 samples were analyzed, of which 53,366 tests (7.9%) were SARS-CoV-2 positive. The number of reinfections varied between 260 (0.52%) for an interval of 2 weeks, 89 (0.19%) for 4 weeks, 52 (0.11%) for 8 weeks, and 37 (0.09%) for a minimum interval of 16 weeks between positive tests. The median Cp-value (IQR) in the second positive samples decreased when a longer interval was chosen, but stabilized from week 8 onwards. Conclusions: Although the calculated reinfection prevalence was relatively low (0.11% for the 8-week time interval), choosing a different minimum interval between two positive tests resulted in major differences in reinfection rates. As reinfection Cp-values stabilized after 8 weeks, we hypothesize this interval to best reflect novel infection rather than persistent shedding. MDPI 2022-03-15 /pmc/articles/PMC8947046/ /pubmed/35328272 http://dx.doi.org/10.3390/diagnostics12030719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Euser, Sjoerd M. Weenink, Tieme Prins, Jan M. Haverkort, Milly Manders, Irene van Lelyveld, Steven Herpers, Bjorn L. Sinnige, Jan Kalpoe, Jayant Snijders, Dominic Cohen Stuart, James Slijkerman Megelink, Fred Kapteijns, Erik den Boer, Jeroen Wagemakers, Alex Souverein, Dennis The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study |
title | The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study |
title_full | The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study |
title_fullStr | The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study |
title_full_unstemmed | The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study |
title_short | The Effect of Varying Interval Definitions on the Prevalence of SARS-CoV-2 Reinfections: A Retrospective Cross-Sectional Cohort Study |
title_sort | effect of varying interval definitions on the prevalence of sars-cov-2 reinfections: a retrospective cross-sectional cohort study |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947046/ https://www.ncbi.nlm.nih.gov/pubmed/35328272 http://dx.doi.org/10.3390/diagnostics12030719 |
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