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Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile

Previous studies associated high-level exposure to ultraviolet radiation with a greater risk of cutaneous malignant melanoma (CMM). This study focuses on the changing incidence of CMM over time (from 1990 to 2017) in the Veneto region of Northeast Italy, and its Alpine area (the province of Belluno)...

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Autores principales: Buja, Alessandra, Rugge, Massimo, De Luca, Giuseppe, Bovo, Emanuela, Zorzi, Manuel, De Toni, Chiara, Cozzolino, Claudia, Vecchiato, Antonella, Del Fiore, Paolo, Spina, Romina, Cinquetti, Sandro, Baldo, Vincenzo, Rossi, Carlo Riccardo, Mocellin, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947100/
https://www.ncbi.nlm.nih.gov/pubmed/35323375
http://dx.doi.org/10.3390/curroncol29030175
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author Buja, Alessandra
Rugge, Massimo
De Luca, Giuseppe
Bovo, Emanuela
Zorzi, Manuel
De Toni, Chiara
Cozzolino, Claudia
Vecchiato, Antonella
Del Fiore, Paolo
Spina, Romina
Cinquetti, Sandro
Baldo, Vincenzo
Rossi, Carlo Riccardo
Mocellin, Simone
author_facet Buja, Alessandra
Rugge, Massimo
De Luca, Giuseppe
Bovo, Emanuela
Zorzi, Manuel
De Toni, Chiara
Cozzolino, Claudia
Vecchiato, Antonella
Del Fiore, Paolo
Spina, Romina
Cinquetti, Sandro
Baldo, Vincenzo
Rossi, Carlo Riccardo
Mocellin, Simone
author_sort Buja, Alessandra
collection PubMed
description Previous studies associated high-level exposure to ultraviolet radiation with a greater risk of cutaneous malignant melanoma (CMM). This study focuses on the changing incidence of CMM over time (from 1990 to 2017) in the Veneto region of Northeast Italy, and its Alpine area (the province of Belluno). The clinicopathological profile of CMM by residence is also considered. A joinpoint regression analysis was performed to identify significant changes in the yearly incidence of CMM by sex and age. For each trend, the average annual percent change (AAPC) was also calculated. In the 2017 CMM cohort, the study includes a descriptive analysis of the disease’s categorical clinicopathological variables. In the population investigated, the incidence of CMM has increased significantly over the last 30 years. The AAPC in the incidence of CMM was significantly higher among Alpine residents aged 0–49 than for the rest of the region’s population (males: 6.9 versus 2.4; females 7.7 versus 2.7, respectively). Among the Alpine residents, the AAPC was 3.35 times greater for females aged 0–49 than for people aged 50+. The clinicopathological profile of CMM was significantly associated with the place of residence. Over three decades, the Veneto population has observed a significant increase in the incidence of CMM, and its AAPC. Both trends have been markedly more pronounced among Alpine residents, particularly younger females. While epidemiology and clinicopathological profiles support the role of UV radiation in CMM, the young age of this CMM-affected female population points to other possible host-related etiological factors. These findings also confirm the importance of primary and secondary prevention strategies.
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spelling pubmed-89471002022-03-25 Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile Buja, Alessandra Rugge, Massimo De Luca, Giuseppe Bovo, Emanuela Zorzi, Manuel De Toni, Chiara Cozzolino, Claudia Vecchiato, Antonella Del Fiore, Paolo Spina, Romina Cinquetti, Sandro Baldo, Vincenzo Rossi, Carlo Riccardo Mocellin, Simone Curr Oncol Article Previous studies associated high-level exposure to ultraviolet radiation with a greater risk of cutaneous malignant melanoma (CMM). This study focuses on the changing incidence of CMM over time (from 1990 to 2017) in the Veneto region of Northeast Italy, and its Alpine area (the province of Belluno). The clinicopathological profile of CMM by residence is also considered. A joinpoint regression analysis was performed to identify significant changes in the yearly incidence of CMM by sex and age. For each trend, the average annual percent change (AAPC) was also calculated. In the 2017 CMM cohort, the study includes a descriptive analysis of the disease’s categorical clinicopathological variables. In the population investigated, the incidence of CMM has increased significantly over the last 30 years. The AAPC in the incidence of CMM was significantly higher among Alpine residents aged 0–49 than for the rest of the region’s population (males: 6.9 versus 2.4; females 7.7 versus 2.7, respectively). Among the Alpine residents, the AAPC was 3.35 times greater for females aged 0–49 than for people aged 50+. The clinicopathological profile of CMM was significantly associated with the place of residence. Over three decades, the Veneto population has observed a significant increase in the incidence of CMM, and its AAPC. Both trends have been markedly more pronounced among Alpine residents, particularly younger females. While epidemiology and clinicopathological profiles support the role of UV radiation in CMM, the young age of this CMM-affected female population points to other possible host-related etiological factors. These findings also confirm the importance of primary and secondary prevention strategies. MDPI 2022-03-21 /pmc/articles/PMC8947100/ /pubmed/35323375 http://dx.doi.org/10.3390/curroncol29030175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buja, Alessandra
Rugge, Massimo
De Luca, Giuseppe
Bovo, Emanuela
Zorzi, Manuel
De Toni, Chiara
Cozzolino, Claudia
Vecchiato, Antonella
Del Fiore, Paolo
Spina, Romina
Cinquetti, Sandro
Baldo, Vincenzo
Rossi, Carlo Riccardo
Mocellin, Simone
Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile
title Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile
title_full Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile
title_fullStr Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile
title_full_unstemmed Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile
title_short Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile
title_sort cutaneous melanoma in alpine population: incidence trends and clinicopathological profile
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947100/
https://www.ncbi.nlm.nih.gov/pubmed/35323375
http://dx.doi.org/10.3390/curroncol29030175
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