Cargando…

Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19

Background: Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. The prevalence and prognostic value of SARS-CoV-2-induced kidney impairment remain controversial. The current study aimed to provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Haifeng, Zhang, Zili, Dobrinina, Maria, Dong, Yalan, Kang, Zhenyu, Chereshnev, Valerii, Hu, Desheng, Zhang, Zhe, Zhang, Jun, Sarapultsev, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947192/
https://www.ncbi.nlm.nih.gov/pubmed/35328155
http://dx.doi.org/10.3390/diagnostics12030602
_version_ 1784674380597428224
author Zhou, Haifeng
Zhang, Zili
Dobrinina, Maria
Dong, Yalan
Kang, Zhenyu
Chereshnev, Valerii
Hu, Desheng
Zhang, Zhe
Zhang, Jun
Sarapultsev, Alexey
author_facet Zhou, Haifeng
Zhang, Zili
Dobrinina, Maria
Dong, Yalan
Kang, Zhenyu
Chereshnev, Valerii
Hu, Desheng
Zhang, Zhe
Zhang, Jun
Sarapultsev, Alexey
author_sort Zhou, Haifeng
collection PubMed
description Background: Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. The prevalence and prognostic value of SARS-CoV-2-induced kidney impairment remain controversial. The current study aimed to provide additional evidence on the incidence of acute kidney injury (AKI) in COVID-19 patients and propose the use of urinalysis as a tool for screening kidney impairment. Methods: 178 patients with confirmed COVID-19 were enrolled in this retrospective cohort study. The laboratory examinations included routine blood tests, blood biochemical analyses (liver function, renal function, lipids, and glucose), blood coagulation index, lymphocyte subset and cytokine analysis, urine routine test, C-reactive protein, erythrocyte sedimentation, and serum ferritin. Results: No patient exhibited a rise in serum creatinine or Cystatin C and occurrence of AKI, and only 2.8% of patients were recorded with an elevated level of blood urea nitrogen among all cases. On the contrary, 54.2% of patients who underwent routine urine testing presented with an abnormal urinalysis as featured by proteinuria, hematuria, and leucocyturia. Conclusions: Kidney impairment is prevalent among COVID-19 patients, with an abnormal urinalysis as a clinical manifestation, implying that a routine urine test is a stronger indication of prospective kidney complication than a blood biochemistry test.
format Online
Article
Text
id pubmed-8947192
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89471922022-03-25 Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19 Zhou, Haifeng Zhang, Zili Dobrinina, Maria Dong, Yalan Kang, Zhenyu Chereshnev, Valerii Hu, Desheng Zhang, Zhe Zhang, Jun Sarapultsev, Alexey Diagnostics (Basel) Article Background: Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. The prevalence and prognostic value of SARS-CoV-2-induced kidney impairment remain controversial. The current study aimed to provide additional evidence on the incidence of acute kidney injury (AKI) in COVID-19 patients and propose the use of urinalysis as a tool for screening kidney impairment. Methods: 178 patients with confirmed COVID-19 were enrolled in this retrospective cohort study. The laboratory examinations included routine blood tests, blood biochemical analyses (liver function, renal function, lipids, and glucose), blood coagulation index, lymphocyte subset and cytokine analysis, urine routine test, C-reactive protein, erythrocyte sedimentation, and serum ferritin. Results: No patient exhibited a rise in serum creatinine or Cystatin C and occurrence of AKI, and only 2.8% of patients were recorded with an elevated level of blood urea nitrogen among all cases. On the contrary, 54.2% of patients who underwent routine urine testing presented with an abnormal urinalysis as featured by proteinuria, hematuria, and leucocyturia. Conclusions: Kidney impairment is prevalent among COVID-19 patients, with an abnormal urinalysis as a clinical manifestation, implying that a routine urine test is a stronger indication of prospective kidney complication than a blood biochemistry test. MDPI 2022-02-27 /pmc/articles/PMC8947192/ /pubmed/35328155 http://dx.doi.org/10.3390/diagnostics12030602 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Haifeng
Zhang, Zili
Dobrinina, Maria
Dong, Yalan
Kang, Zhenyu
Chereshnev, Valerii
Hu, Desheng
Zhang, Zhe
Zhang, Jun
Sarapultsev, Alexey
Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19
title Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19
title_full Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19
title_fullStr Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19
title_full_unstemmed Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19
title_short Urinalysis, but Not Blood Biochemistry, Detects the Early Renal Impairment in Patients with COVID-19
title_sort urinalysis, but not blood biochemistry, detects the early renal impairment in patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947192/
https://www.ncbi.nlm.nih.gov/pubmed/35328155
http://dx.doi.org/10.3390/diagnostics12030602
work_keys_str_mv AT zhouhaifeng urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT zhangzili urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT dobrininamaria urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT dongyalan urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT kangzhenyu urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT chereshnevvalerii urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT hudesheng urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT zhangzhe urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT zhangjun urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19
AT sarapultsevalexey urinalysisbutnotbloodbiochemistrydetectstheearlyrenalimpairmentinpatientswithcovid19