Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children

We quantified antibiotic resistance genes before and after short antibiotic courses in nasopharyngeal specimens from ambulatory children. Carriage of certain bacteria and resistance genes was common before antibiotics. After antibiotics, we observed substantial reductions in pneumococcal and Staphyl...

Descripción completa

Detalles Bibliográficos
Autores principales: Howard, Leigh M, Dantuluri, Keerti L, Soper, Nicole, Thomsen, Isaac P, Grijalva, Carlos G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947223/
https://www.ncbi.nlm.nih.gov/pubmed/35350815
http://dx.doi.org/10.1093/ofid/ofab519
_version_ 1784674386726354944
author Howard, Leigh M
Dantuluri, Keerti L
Soper, Nicole
Thomsen, Isaac P
Grijalva, Carlos G
author_facet Howard, Leigh M
Dantuluri, Keerti L
Soper, Nicole
Thomsen, Isaac P
Grijalva, Carlos G
author_sort Howard, Leigh M
collection PubMed
description We quantified antibiotic resistance genes before and after short antibiotic courses in nasopharyngeal specimens from ambulatory children. Carriage of certain bacteria and resistance genes was common before antibiotics. After antibiotics, we observed substantial reductions in pneumococcal and Staphylococcus aureus carriage and rapid expansion in the abundance of certain resistance genes.
format Online
Article
Text
id pubmed-8947223
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-89472232022-03-28 Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children Howard, Leigh M Dantuluri, Keerti L Soper, Nicole Thomsen, Isaac P Grijalva, Carlos G Open Forum Infect Dis Brief Reports We quantified antibiotic resistance genes before and after short antibiotic courses in nasopharyngeal specimens from ambulatory children. Carriage of certain bacteria and resistance genes was common before antibiotics. After antibiotics, we observed substantial reductions in pneumococcal and Staphylococcus aureus carriage and rapid expansion in the abundance of certain resistance genes. Oxford University Press 2021-10-16 /pmc/articles/PMC8947223/ /pubmed/35350815 http://dx.doi.org/10.1093/ofid/ofab519 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Howard, Leigh M
Dantuluri, Keerti L
Soper, Nicole
Thomsen, Isaac P
Grijalva, Carlos G
Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children
title Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children
title_full Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children
title_fullStr Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children
title_full_unstemmed Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children
title_short Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children
title_sort rapid changes in nasopharyngeal antibiotic resistance gene profiles after short courses of antibiotics in a pilot study of ambulatory young children
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947223/
https://www.ncbi.nlm.nih.gov/pubmed/35350815
http://dx.doi.org/10.1093/ofid/ofab519
work_keys_str_mv AT howardleighm rapidchangesinnasopharyngealantibioticresistancegeneprofilesaftershortcoursesofantibioticsinapilotstudyofambulatoryyoungchildren
AT dantulurikeertil rapidchangesinnasopharyngealantibioticresistancegeneprofilesaftershortcoursesofantibioticsinapilotstudyofambulatoryyoungchildren
AT sopernicole rapidchangesinnasopharyngealantibioticresistancegeneprofilesaftershortcoursesofantibioticsinapilotstudyofambulatoryyoungchildren
AT thomsenisaacp rapidchangesinnasopharyngealantibioticresistancegeneprofilesaftershortcoursesofantibioticsinapilotstudyofambulatoryyoungchildren
AT grijalvacarlosg rapidchangesinnasopharyngealantibioticresistancegeneprofilesaftershortcoursesofantibioticsinapilotstudyofambulatoryyoungchildren

Ejemplares similares