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Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand

The lack of appropriate medicines for children has a significant impact on health care practices in various countries around the world, including Thailand. The unavailability of pediatric medicines in hospital formularies causes issues regarding off-label use and extemporaneous preparation, resultin...

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Autores principales: Tiengkate, Prangthong, Lallemant, Marc, Charoenkwan, Pimlak, Angkurawaranon, Chaisiri, Kanjanarat, Penkarn, Suwannaprom, Puckwipa, Borriharn, Phetlada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947278/
https://www.ncbi.nlm.nih.gov/pubmed/35327673
http://dx.doi.org/10.3390/children9030301
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author Tiengkate, Prangthong
Lallemant, Marc
Charoenkwan, Pimlak
Angkurawaranon, Chaisiri
Kanjanarat, Penkarn
Suwannaprom, Puckwipa
Borriharn, Phetlada
author_facet Tiengkate, Prangthong
Lallemant, Marc
Charoenkwan, Pimlak
Angkurawaranon, Chaisiri
Kanjanarat, Penkarn
Suwannaprom, Puckwipa
Borriharn, Phetlada
author_sort Tiengkate, Prangthong
collection PubMed
description The lack of appropriate medicines for children has a significant impact on health care practices in various countries around the world, including Thailand. The unavailability of pediatric medicines in hospital formularies causes issues regarding off-label use and extemporaneous preparation, resulting in safety and quality risks relating to the use of medicines among children. This research aimed to identify missing pediatric formulations based on the experience of healthcare professionals in a teaching hospital in northern Thailand. A cross-sectional survey was conducted to collect data on missing pediatric formulations, the reasons for their inaccessibility, their off-label uses, their reactions to the situation, and suggestions to improve access to these identified medications. The survey was distributed to all physicians, nurses, and pharmacists involved in prescribing, preparing, dispensing, and administering pediatric medicines. A total of 218 subjects responded to the survey. Omeprazole, sildenafil, and spironolactone suspension were most often identified as missing formulations for children by physicians and pharmacists. They are unavailable on the Thai market or in any hospital formulary. For nurses, sodium bicarbonate, potassium chloride, and chloral hydrate were the most problematic formulations in terms of preparation, acceptability, and administration. These medicines were difficult to swallow because of their taste or texture.
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spelling pubmed-89472782022-03-25 Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand Tiengkate, Prangthong Lallemant, Marc Charoenkwan, Pimlak Angkurawaranon, Chaisiri Kanjanarat, Penkarn Suwannaprom, Puckwipa Borriharn, Phetlada Children (Basel) Article The lack of appropriate medicines for children has a significant impact on health care practices in various countries around the world, including Thailand. The unavailability of pediatric medicines in hospital formularies causes issues regarding off-label use and extemporaneous preparation, resulting in safety and quality risks relating to the use of medicines among children. This research aimed to identify missing pediatric formulations based on the experience of healthcare professionals in a teaching hospital in northern Thailand. A cross-sectional survey was conducted to collect data on missing pediatric formulations, the reasons for their inaccessibility, their off-label uses, their reactions to the situation, and suggestions to improve access to these identified medications. The survey was distributed to all physicians, nurses, and pharmacists involved in prescribing, preparing, dispensing, and administering pediatric medicines. A total of 218 subjects responded to the survey. Omeprazole, sildenafil, and spironolactone suspension were most often identified as missing formulations for children by physicians and pharmacists. They are unavailable on the Thai market or in any hospital formulary. For nurses, sodium bicarbonate, potassium chloride, and chloral hydrate were the most problematic formulations in terms of preparation, acceptability, and administration. These medicines were difficult to swallow because of their taste or texture. MDPI 2022-02-22 /pmc/articles/PMC8947278/ /pubmed/35327673 http://dx.doi.org/10.3390/children9030301 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tiengkate, Prangthong
Lallemant, Marc
Charoenkwan, Pimlak
Angkurawaranon, Chaisiri
Kanjanarat, Penkarn
Suwannaprom, Puckwipa
Borriharn, Phetlada
Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand
title Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand
title_full Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand
title_fullStr Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand
title_full_unstemmed Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand
title_short Gaps in Accessibility of Pediatric Formulations: A Cross-Sectional Observational Study of a Teaching Hospital in Northern Thailand
title_sort gaps in accessibility of pediatric formulations: a cross-sectional observational study of a teaching hospital in northern thailand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947278/
https://www.ncbi.nlm.nih.gov/pubmed/35327673
http://dx.doi.org/10.3390/children9030301
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