Cargando…

The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence

Background: Impaired weight gain is prevalent in Robin Sequence (RS) newborns. Although mandibular distraction osteogenesis (MDO) has been proven to improve oral feeding, its impact on postoperative weight gain remains unclear. The purpose of this study is to explore whether MDO can help RS babies r...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Zhe, Battaglino, Ricardo, Zhou, Jiawei, Cui, Yingqiu, Shrivastava, Mayank, Tian, Gabriel, Sahebdel, Faezeh, Ye, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947281/
https://www.ncbi.nlm.nih.gov/pubmed/35327691
http://dx.doi.org/10.3390/children9030319
_version_ 1784674402344894464
author Mao, Zhe
Battaglino, Ricardo
Zhou, Jiawei
Cui, Yingqiu
Shrivastava, Mayank
Tian, Gabriel
Sahebdel, Faezeh
Ye, Liang
author_facet Mao, Zhe
Battaglino, Ricardo
Zhou, Jiawei
Cui, Yingqiu
Shrivastava, Mayank
Tian, Gabriel
Sahebdel, Faezeh
Ye, Liang
author_sort Mao, Zhe
collection PubMed
description Background: Impaired weight gain is prevalent in Robin Sequence (RS) newborns. Although mandibular distraction osteogenesis (MDO) has been proven to improve oral feeding, its impact on postoperative weight gain remains unclear. The purpose of this study is to explore whether MDO can help RS babies reach a normal weight, as well as the effect of MDO timing on weight velocity. Methods: One hundred infants with severe RS and one hundred with normal controls met the inclusion criteria for the study. Included patients underwent MDO. Weights at different timing points were recorded and analyzed and compared to normal controls. Results: After the distractor removal weights of patients undergoing MDO at <1 month and 1–2 months were close to the normal control (6.81 ± 0.93 kg versus 7.18 ± 0.61 kg, p = 0.012, and 6.82 ± 0.98 kg versus 7.37 ± 0.75 kg, p = 0.033, respectively), the weights of patients undergoing MDO at 2–3 months and 3–4 months still lagged behind (7.56 ± 1.29 kg versus 8.20 ± 0.61 kg, p = 0.000206 and 7.36 ± 1.05 kg versus 8.25 ± 0.77 kg, p = 0.004, respectively). The weights of all RS infants undergoing MDO showed no significant difference compared to the controls when they aged to 1 year (9.34 ± 0.99 kg versus 9.55 ± 0.45 kg, p = 0.254 for MDO at <1 month; 9.12 ± 0.91 kg versus 9.33 ± 0.46 kg, p = 0.100 for MDO at 1 to 2 months; 9.38 ± 0.29 kg versus 9.83 ± 0.53 kg, p = 0.098 for MDO at 2 to 3 months; and 9.38 ± 0.29 kg versus 9.83 ± 0.53 kg, p = 0.098 for MDO at 3 to 4 months). Conclusion: The MDO procedure helped patients with severe RS to reach a normal weight; and MDO intervention was recommended at an early stage for early weight gain.
format Online
Article
Text
id pubmed-8947281
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89472812022-03-25 The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence Mao, Zhe Battaglino, Ricardo Zhou, Jiawei Cui, Yingqiu Shrivastava, Mayank Tian, Gabriel Sahebdel, Faezeh Ye, Liang Children (Basel) Article Background: Impaired weight gain is prevalent in Robin Sequence (RS) newborns. Although mandibular distraction osteogenesis (MDO) has been proven to improve oral feeding, its impact on postoperative weight gain remains unclear. The purpose of this study is to explore whether MDO can help RS babies reach a normal weight, as well as the effect of MDO timing on weight velocity. Methods: One hundred infants with severe RS and one hundred with normal controls met the inclusion criteria for the study. Included patients underwent MDO. Weights at different timing points were recorded and analyzed and compared to normal controls. Results: After the distractor removal weights of patients undergoing MDO at <1 month and 1–2 months were close to the normal control (6.81 ± 0.93 kg versus 7.18 ± 0.61 kg, p = 0.012, and 6.82 ± 0.98 kg versus 7.37 ± 0.75 kg, p = 0.033, respectively), the weights of patients undergoing MDO at 2–3 months and 3–4 months still lagged behind (7.56 ± 1.29 kg versus 8.20 ± 0.61 kg, p = 0.000206 and 7.36 ± 1.05 kg versus 8.25 ± 0.77 kg, p = 0.004, respectively). The weights of all RS infants undergoing MDO showed no significant difference compared to the controls when they aged to 1 year (9.34 ± 0.99 kg versus 9.55 ± 0.45 kg, p = 0.254 for MDO at <1 month; 9.12 ± 0.91 kg versus 9.33 ± 0.46 kg, p = 0.100 for MDO at 1 to 2 months; 9.38 ± 0.29 kg versus 9.83 ± 0.53 kg, p = 0.098 for MDO at 2 to 3 months; and 9.38 ± 0.29 kg versus 9.83 ± 0.53 kg, p = 0.098 for MDO at 3 to 4 months). Conclusion: The MDO procedure helped patients with severe RS to reach a normal weight; and MDO intervention was recommended at an early stage for early weight gain. MDPI 2022-02-28 /pmc/articles/PMC8947281/ /pubmed/35327691 http://dx.doi.org/10.3390/children9030319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mao, Zhe
Battaglino, Ricardo
Zhou, Jiawei
Cui, Yingqiu
Shrivastava, Mayank
Tian, Gabriel
Sahebdel, Faezeh
Ye, Liang
The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence
title The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence
title_full The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence
title_fullStr The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence
title_full_unstemmed The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence
title_short The Effect of Timing of Mandibular Distraction Osteogenesis on Weight Velocity in Infants Affected by Severe Robin Sequence
title_sort effect of timing of mandibular distraction osteogenesis on weight velocity in infants affected by severe robin sequence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947281/
https://www.ncbi.nlm.nih.gov/pubmed/35327691
http://dx.doi.org/10.3390/children9030319
work_keys_str_mv AT maozhe theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT battaglinoricardo theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT zhoujiawei theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT cuiyingqiu theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT shrivastavamayank theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT tiangabriel theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT sahebdelfaezeh theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT yeliang theeffectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT maozhe effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT battaglinoricardo effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT zhoujiawei effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT cuiyingqiu effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT shrivastavamayank effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT tiangabriel effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT sahebdelfaezeh effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence
AT yeliang effectoftimingofmandibulardistractionosteogenesisonweightvelocityininfantsaffectedbysevererobinsequence