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Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player in lipid metabolism, as it degrades low-density lipoprotein (LDL) receptors from hepatic cell membranes. So far, only variants of the PCSK9 gene locus were found to be associated with PCSK9 levels. Here we aimed to ide...

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Detalles Bibliográficos
Autores principales:	Pott, Janne, Gådin, Jesper R, Theusch, Elizabeth, Kleber, Marcus E, Delgado, Graciela E, Kirsten, Holger, Hauck, Stefanie M, Burkhardt, Ralph, Scharnagl, Hubert, Krauss, Ronald M, Loeffler, Markus, März, Winfried, Thiery, Joachim, Silveira, Angela, van't Hooft, Ferdinand M, Scholz, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Association Studies Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947322/ https://www.ncbi.nlm.nih.gov/pubmed/34590679 http://dx.doi.org/10.1093/hmg/ddab279

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