Cargando…

Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia

Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is su...

Descripción completa

Detalles Bibliográficos
Autores principales: Vudatha, Vignesh, Devarakonda, Teja, Liu, Christopher, Freudenberger, Devon C., Riner, Andrea N., Herremans, Kelly M., Trevino, Jose G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947347/
https://www.ncbi.nlm.nih.gov/pubmed/35326491
http://dx.doi.org/10.3390/cells11061040
_version_ 1784674417704435712
author Vudatha, Vignesh
Devarakonda, Teja
Liu, Christopher
Freudenberger, Devon C.
Riner, Andrea N.
Herremans, Kelly M.
Trevino, Jose G.
author_facet Vudatha, Vignesh
Devarakonda, Teja
Liu, Christopher
Freudenberger, Devon C.
Riner, Andrea N.
Herremans, Kelly M.
Trevino, Jose G.
author_sort Vudatha, Vignesh
collection PubMed
description Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed.
format Online
Article
Text
id pubmed-8947347
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89473472022-03-25 Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia Vudatha, Vignesh Devarakonda, Teja Liu, Christopher Freudenberger, Devon C. Riner, Andrea N. Herremans, Kelly M. Trevino, Jose G. Cells Review Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed. MDPI 2022-03-18 /pmc/articles/PMC8947347/ /pubmed/35326491 http://dx.doi.org/10.3390/cells11061040 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vudatha, Vignesh
Devarakonda, Teja
Liu, Christopher
Freudenberger, Devon C.
Riner, Andrea N.
Herremans, Kelly M.
Trevino, Jose G.
Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
title Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
title_full Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
title_fullStr Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
title_full_unstemmed Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
title_short Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
title_sort review of mechanisms and treatment of cancer-induced cardiac cachexia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947347/
https://www.ncbi.nlm.nih.gov/pubmed/35326491
http://dx.doi.org/10.3390/cells11061040
work_keys_str_mv AT vudathavignesh reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia
AT devarakondateja reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia
AT liuchristopher reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia
AT freudenbergerdevonc reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia
AT rinerandrean reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia
AT herremanskellym reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia
AT trevinojoseg reviewofmechanismsandtreatmentofcancerinducedcardiaccachexia