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Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is su...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947347/ https://www.ncbi.nlm.nih.gov/pubmed/35326491 http://dx.doi.org/10.3390/cells11061040 |
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author | Vudatha, Vignesh Devarakonda, Teja Liu, Christopher Freudenberger, Devon C. Riner, Andrea N. Herremans, Kelly M. Trevino, Jose G. |
author_facet | Vudatha, Vignesh Devarakonda, Teja Liu, Christopher Freudenberger, Devon C. Riner, Andrea N. Herremans, Kelly M. Trevino, Jose G. |
author_sort | Vudatha, Vignesh |
collection | PubMed |
description | Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed. |
format | Online Article Text |
id | pubmed-8947347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89473472022-03-25 Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia Vudatha, Vignesh Devarakonda, Teja Liu, Christopher Freudenberger, Devon C. Riner, Andrea N. Herremans, Kelly M. Trevino, Jose G. Cells Review Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed. MDPI 2022-03-18 /pmc/articles/PMC8947347/ /pubmed/35326491 http://dx.doi.org/10.3390/cells11061040 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vudatha, Vignesh Devarakonda, Teja Liu, Christopher Freudenberger, Devon C. Riner, Andrea N. Herremans, Kelly M. Trevino, Jose G. Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
title | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
title_full | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
title_fullStr | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
title_full_unstemmed | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
title_short | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
title_sort | review of mechanisms and treatment of cancer-induced cardiac cachexia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947347/ https://www.ncbi.nlm.nih.gov/pubmed/35326491 http://dx.doi.org/10.3390/cells11061040 |
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