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Sclerodermic Cardiomyopathy—A State-of-the-Art Review
Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947572/ https://www.ncbi.nlm.nih.gov/pubmed/35328222 http://dx.doi.org/10.3390/diagnostics12030669 |
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author | Giucă, Adrian Gegenava, Tea Mihai, Carmen Marina Jurcuţ, Ciprian Săftoiu, Adrian Gȋrniţă, Diana Monica Popescu, Bogdan Alexandru Ajmone Marsan, Nina Jurcuț, Ruxandra |
author_facet | Giucă, Adrian Gegenava, Tea Mihai, Carmen Marina Jurcuţ, Ciprian Săftoiu, Adrian Gȋrniţă, Diana Monica Popescu, Bogdan Alexandru Ajmone Marsan, Nina Jurcuț, Ruxandra |
author_sort | Giucă, Adrian |
collection | PubMed |
description | Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imaging techniques (transthoracic 2D and 3D echocardiography, cardiac magnetic resonance (CMR), and novel imaging techniques, including myocardial deformation analysis) provide new insights into the cardiac abnormalities in patients with SSc. This state-of-the-art review aims to stratify all the cardiac investigations needed to diagnose and follow-up the SScCmp, and discusses the epidemiology, risk factors and pathophysiology of this important cause of morbidity of the SSc patient. |
format | Online Article Text |
id | pubmed-8947572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89475722022-03-25 Sclerodermic Cardiomyopathy—A State-of-the-Art Review Giucă, Adrian Gegenava, Tea Mihai, Carmen Marina Jurcuţ, Ciprian Săftoiu, Adrian Gȋrniţă, Diana Monica Popescu, Bogdan Alexandru Ajmone Marsan, Nina Jurcuț, Ruxandra Diagnostics (Basel) Review Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imaging techniques (transthoracic 2D and 3D echocardiography, cardiac magnetic resonance (CMR), and novel imaging techniques, including myocardial deformation analysis) provide new insights into the cardiac abnormalities in patients with SSc. This state-of-the-art review aims to stratify all the cardiac investigations needed to diagnose and follow-up the SScCmp, and discusses the epidemiology, risk factors and pathophysiology of this important cause of morbidity of the SSc patient. MDPI 2022-03-09 /pmc/articles/PMC8947572/ /pubmed/35328222 http://dx.doi.org/10.3390/diagnostics12030669 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Giucă, Adrian Gegenava, Tea Mihai, Carmen Marina Jurcuţ, Ciprian Săftoiu, Adrian Gȋrniţă, Diana Monica Popescu, Bogdan Alexandru Ajmone Marsan, Nina Jurcuț, Ruxandra Sclerodermic Cardiomyopathy—A State-of-the-Art Review |
title | Sclerodermic Cardiomyopathy—A State-of-the-Art Review |
title_full | Sclerodermic Cardiomyopathy—A State-of-the-Art Review |
title_fullStr | Sclerodermic Cardiomyopathy—A State-of-the-Art Review |
title_full_unstemmed | Sclerodermic Cardiomyopathy—A State-of-the-Art Review |
title_short | Sclerodermic Cardiomyopathy—A State-of-the-Art Review |
title_sort | sclerodermic cardiomyopathy—a state-of-the-art review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947572/ https://www.ncbi.nlm.nih.gov/pubmed/35328222 http://dx.doi.org/10.3390/diagnostics12030669 |
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