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Sclerodermic Cardiomyopathy—A State-of-the-Art Review

Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, s...

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Autores principales: Giucă, Adrian, Gegenava, Tea, Mihai, Carmen Marina, Jurcuţ, Ciprian, Săftoiu, Adrian, Gȋrniţă, Diana Monica, Popescu, Bogdan Alexandru, Ajmone Marsan, Nina, Jurcuț, Ruxandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947572/
https://www.ncbi.nlm.nih.gov/pubmed/35328222
http://dx.doi.org/10.3390/diagnostics12030669
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author Giucă, Adrian
Gegenava, Tea
Mihai, Carmen Marina
Jurcuţ, Ciprian
Săftoiu, Adrian
Gȋrniţă, Diana Monica
Popescu, Bogdan Alexandru
Ajmone Marsan, Nina
Jurcuț, Ruxandra
author_facet Giucă, Adrian
Gegenava, Tea
Mihai, Carmen Marina
Jurcuţ, Ciprian
Săftoiu, Adrian
Gȋrniţă, Diana Monica
Popescu, Bogdan Alexandru
Ajmone Marsan, Nina
Jurcuț, Ruxandra
author_sort Giucă, Adrian
collection PubMed
description Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imaging techniques (transthoracic 2D and 3D echocardiography, cardiac magnetic resonance (CMR), and novel imaging techniques, including myocardial deformation analysis) provide new insights into the cardiac abnormalities in patients with SSc. This state-of-the-art review aims to stratify all the cardiac investigations needed to diagnose and follow-up the SScCmp, and discusses the epidemiology, risk factors and pathophysiology of this important cause of morbidity of the SSc patient.
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spelling pubmed-89475722022-03-25 Sclerodermic Cardiomyopathy—A State-of-the-Art Review Giucă, Adrian Gegenava, Tea Mihai, Carmen Marina Jurcuţ, Ciprian Săftoiu, Adrian Gȋrniţă, Diana Monica Popescu, Bogdan Alexandru Ajmone Marsan, Nina Jurcuț, Ruxandra Diagnostics (Basel) Review Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imaging techniques (transthoracic 2D and 3D echocardiography, cardiac magnetic resonance (CMR), and novel imaging techniques, including myocardial deformation analysis) provide new insights into the cardiac abnormalities in patients with SSc. This state-of-the-art review aims to stratify all the cardiac investigations needed to diagnose and follow-up the SScCmp, and discusses the epidemiology, risk factors and pathophysiology of this important cause of morbidity of the SSc patient. MDPI 2022-03-09 /pmc/articles/PMC8947572/ /pubmed/35328222 http://dx.doi.org/10.3390/diagnostics12030669 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giucă, Adrian
Gegenava, Tea
Mihai, Carmen Marina
Jurcuţ, Ciprian
Săftoiu, Adrian
Gȋrniţă, Diana Monica
Popescu, Bogdan Alexandru
Ajmone Marsan, Nina
Jurcuț, Ruxandra
Sclerodermic Cardiomyopathy—A State-of-the-Art Review
title Sclerodermic Cardiomyopathy—A State-of-the-Art Review
title_full Sclerodermic Cardiomyopathy—A State-of-the-Art Review
title_fullStr Sclerodermic Cardiomyopathy—A State-of-the-Art Review
title_full_unstemmed Sclerodermic Cardiomyopathy—A State-of-the-Art Review
title_short Sclerodermic Cardiomyopathy—A State-of-the-Art Review
title_sort sclerodermic cardiomyopathy—a state-of-the-art review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947572/
https://www.ncbi.nlm.nih.gov/pubmed/35328222
http://dx.doi.org/10.3390/diagnostics12030669
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