A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism

Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has limited effect in cell viability but inactivation of both genes simultaneously leads to cell death. Given the profound genomic aberrations acquired by...

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Detalles Bibliográficos
Autores principales: Apaolaza, Iñigo, San José-Enériz, Edurne, Valcarcel, Luis V., Agirre, Xabier, Prosper, Felipe, Planes, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947600/
https://www.ncbi.nlm.nih.gov/pubmed/35286311
http://dx.doi.org/10.1371/journal.pcbi.1009395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947600/
https://www.ncbi.nlm.nih.gov/pubmed/35286311
http://dx.doi.org/10.1371/journal.pcbi.1009395

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