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A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism
Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has limited effect in cell viability but inactivation of both genes simultaneously leads to cell death. Given the profound genomic aberrations acquired by...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947600/ https://www.ncbi.nlm.nih.gov/pubmed/35286311 http://dx.doi.org/10.1371/journal.pcbi.1009395 |