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Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects
Developmental defects of enamel (DDEs) are deviations from the normal appearance in terms of the quantity and quality of tooth enamel. They may be genetic or acquired. The most important DDEs are hypomineralization and hypoplasia. The aim of this study was to produce “in vivo” DDE in Wistar rats by...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947673/ https://www.ncbi.nlm.nih.gov/pubmed/35328189 http://dx.doi.org/10.3390/diagnostics12030636 |
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author | Popescu, Mihai Scrieciu, Monica Osiac, Eugen Bătăiosu, Marilena Vlăduțu, Diana Pascu, Roxana Maria Stănuși, Andreea Glodeanu, Adina Dorina Ionescu, Mihaela Mercuț, Veronica |
author_facet | Popescu, Mihai Scrieciu, Monica Osiac, Eugen Bătăiosu, Marilena Vlăduțu, Diana Pascu, Roxana Maria Stănuși, Andreea Glodeanu, Adina Dorina Ionescu, Mihaela Mercuț, Veronica |
author_sort | Popescu, Mihai |
collection | PubMed |
description | Developmental defects of enamel (DDEs) are deviations from the normal appearance in terms of the quantity and quality of tooth enamel. They may be genetic or acquired. The most important DDEs are hypomineralization and hypoplasia. The aim of this study was to produce “in vivo” DDE in Wistar rats by administering amoxicillin to pregnant females and to highlight these lesions after sacrifice of the pups by macroscopic and microscopic examination and optical coherence tomography (OCT). Amoxicillin (100 mg/kg) was administered to two pregnant Wistar female rats for the production of DDEs. When the pups were 2 months old, they were sacrificed, and their jaws were harvested together with their teeth. The jaws were examined macroscopically, microscopically, and by OCT. Following the macroscopic and microscopic examination, it was established that four pups had a total of 42 DDE lesions. At the OCT examination, the hypomineralization was characterized by an intense, inhomogeneous OCT signal, and the hypoplasia was characterized by the absence of the signal. Administration of amoxicillin to pregnant females of Wistar rats resulted in DDEs in their offspring. The OCT examination confirmed the presence of these lesions in the teeth of rat pups. |
format | Online Article Text |
id | pubmed-8947673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89476732022-03-25 Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects Popescu, Mihai Scrieciu, Monica Osiac, Eugen Bătăiosu, Marilena Vlăduțu, Diana Pascu, Roxana Maria Stănuși, Andreea Glodeanu, Adina Dorina Ionescu, Mihaela Mercuț, Veronica Diagnostics (Basel) Article Developmental defects of enamel (DDEs) are deviations from the normal appearance in terms of the quantity and quality of tooth enamel. They may be genetic or acquired. The most important DDEs are hypomineralization and hypoplasia. The aim of this study was to produce “in vivo” DDE in Wistar rats by administering amoxicillin to pregnant females and to highlight these lesions after sacrifice of the pups by macroscopic and microscopic examination and optical coherence tomography (OCT). Amoxicillin (100 mg/kg) was administered to two pregnant Wistar female rats for the production of DDEs. When the pups were 2 months old, they were sacrificed, and their jaws were harvested together with their teeth. The jaws were examined macroscopically, microscopically, and by OCT. Following the macroscopic and microscopic examination, it was established that four pups had a total of 42 DDE lesions. At the OCT examination, the hypomineralization was characterized by an intense, inhomogeneous OCT signal, and the hypoplasia was characterized by the absence of the signal. Administration of amoxicillin to pregnant females of Wistar rats resulted in DDEs in their offspring. The OCT examination confirmed the presence of these lesions in the teeth of rat pups. MDPI 2022-03-05 /pmc/articles/PMC8947673/ /pubmed/35328189 http://dx.doi.org/10.3390/diagnostics12030636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Popescu, Mihai Scrieciu, Monica Osiac, Eugen Bătăiosu, Marilena Vlăduțu, Diana Pascu, Roxana Maria Stănuși, Andreea Glodeanu, Adina Dorina Ionescu, Mihaela Mercuț, Veronica Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects |
title | Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects |
title_full | Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects |
title_fullStr | Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects |
title_full_unstemmed | Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects |
title_short | Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects |
title_sort | applications of optical coherence tomography in the diagnosis of enamel defects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947673/ https://www.ncbi.nlm.nih.gov/pubmed/35328189 http://dx.doi.org/10.3390/diagnostics12030636 |
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