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Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report

Calcium pyrophosphate dihydrate (CPPD) deposition disease is a benign disorder characterized by acute gouty arthritis-like attacks and first reported by McCarty. CPPD deposition disease rarely occurs in the temporomandibular joint (TMJ), and although confirmation of positive birefringence by polariz...

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Autores principales: Terauchi, Masahiko, Uo, Motohiro, Fukawa, Yuki, Yoshitake, Hiroyuki, Tajima, Rina, Ikeda, Tohru, Yoda, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947689/
https://www.ncbi.nlm.nih.gov/pubmed/35328204
http://dx.doi.org/10.3390/diagnostics12030651
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author Terauchi, Masahiko
Uo, Motohiro
Fukawa, Yuki
Yoshitake, Hiroyuki
Tajima, Rina
Ikeda, Tohru
Yoda, Tetsuya
author_facet Terauchi, Masahiko
Uo, Motohiro
Fukawa, Yuki
Yoshitake, Hiroyuki
Tajima, Rina
Ikeda, Tohru
Yoda, Tetsuya
author_sort Terauchi, Masahiko
collection PubMed
description Calcium pyrophosphate dihydrate (CPPD) deposition disease is a benign disorder characterized by acute gouty arthritis-like attacks and first reported by McCarty. CPPD deposition disease rarely occurs in the temporomandibular joint (TMJ), and although confirmation of positive birefringence by polarized light microscopy is important for diagnosis, it is not reliable because other crystals also show birefringence. We reported a case of CPPD deposition disease of the TMJ that was diagnosed by chemical analysis. A 47-year-old man with a chief complaint of persistent pain in the right TMJ and trismus was referred to our department in 2020. Radiographic examination revealed destruction of the head of the mandibular condyle and cranial base with a neoplastic lesion involving calcification tissue. We suspected CPPD deposition disease and performed enucleation of the white, chalky masses. Histopathologically, we confirmed crystal deposition with weak birefringence. SEM/EDS revealed that the light emitting parts of Ca and P corresponded with the bright part of the SEM image. Through X-ray diffraction, almost all peaks were confirmed to be CPPD-derived. Inductively coupled plasma atomic emission spectroscopy revealed a Ca/P ratio of nearly 1. These chemical analyses further support the histological diagnosis of CPPD deposition disease.
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spelling pubmed-89476892022-03-25 Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report Terauchi, Masahiko Uo, Motohiro Fukawa, Yuki Yoshitake, Hiroyuki Tajima, Rina Ikeda, Tohru Yoda, Tetsuya Diagnostics (Basel) Case Report Calcium pyrophosphate dihydrate (CPPD) deposition disease is a benign disorder characterized by acute gouty arthritis-like attacks and first reported by McCarty. CPPD deposition disease rarely occurs in the temporomandibular joint (TMJ), and although confirmation of positive birefringence by polarized light microscopy is important for diagnosis, it is not reliable because other crystals also show birefringence. We reported a case of CPPD deposition disease of the TMJ that was diagnosed by chemical analysis. A 47-year-old man with a chief complaint of persistent pain in the right TMJ and trismus was referred to our department in 2020. Radiographic examination revealed destruction of the head of the mandibular condyle and cranial base with a neoplastic lesion involving calcification tissue. We suspected CPPD deposition disease and performed enucleation of the white, chalky masses. Histopathologically, we confirmed crystal deposition with weak birefringence. SEM/EDS revealed that the light emitting parts of Ca and P corresponded with the bright part of the SEM image. Through X-ray diffraction, almost all peaks were confirmed to be CPPD-derived. Inductively coupled plasma atomic emission spectroscopy revealed a Ca/P ratio of nearly 1. These chemical analyses further support the histological diagnosis of CPPD deposition disease. MDPI 2022-03-07 /pmc/articles/PMC8947689/ /pubmed/35328204 http://dx.doi.org/10.3390/diagnostics12030651 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Terauchi, Masahiko
Uo, Motohiro
Fukawa, Yuki
Yoshitake, Hiroyuki
Tajima, Rina
Ikeda, Tohru
Yoda, Tetsuya
Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report
title Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report
title_full Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report
title_fullStr Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report
title_full_unstemmed Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report
title_short Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report
title_sort chemical diagnosis of calcium pyrophosphate deposition disease of the temporomandibular joint: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947689/
https://www.ncbi.nlm.nih.gov/pubmed/35328204
http://dx.doi.org/10.3390/diagnostics12030651
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