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FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma
This study investigated the prognostic value of FDG PET/CT radiomic features for predicting recurrence in patients with early breast invasive ductal carcinoma (IDC). The medical records of consecutive patients who were newly diagnosed with primary breast IDC after curative surgery were reviewed. Pat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947709/ https://www.ncbi.nlm.nih.gov/pubmed/35328247 http://dx.doi.org/10.3390/diagnostics12030694 |
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author | Jo, Joon-Hyung Chung, Hyun Woo So, Young Yoo, Young Bum Park, Kyoung Sik Nam, Sang Eun Lee, Eun Jeong Noh, Woo Chul |
author_facet | Jo, Joon-Hyung Chung, Hyun Woo So, Young Yoo, Young Bum Park, Kyoung Sik Nam, Sang Eun Lee, Eun Jeong Noh, Woo Chul |
author_sort | Jo, Joon-Hyung |
collection | PubMed |
description | This study investigated the prognostic value of FDG PET/CT radiomic features for predicting recurrence in patients with early breast invasive ductal carcinoma (IDC). The medical records of consecutive patients who were newly diagnosed with primary breast IDC after curative surgery were reviewed. Patients who received any neoadjuvant treatment before surgery were not included. FDG PET/CT radiomic features, such as a maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), skewness, kurtosis, entropy, and uniformity, were measured for the primary breast tumor using LIFEx software to evaluate recurrence-free survival (RFS). A total of 124 patients with early breast IDC were evaluated. Eleven patients had a recurrence (8.9%). Univariate survival analysis identified large tumor size (>2 cm, p = 0.045), high Ki-67 expression (≥30%, p = 0.017), high AJCC prognostic stage (≥II, p = 0.044), high SUVmax (≥5.0, p = 0.002), high MTV (≥3.25 mL, p = 0.044), high TLG (≥10.5, p = 0.004), and high entropy (≥3.15, p = 0.003) as significant predictors of poor RFS. After multivariate survival analysis, only high MTV (p = 0.045) was an independent prognostic predictor. Evaluation of the MTV of the primary tumor by FDG PET/CT in patients with early breast IDC provides useful prognostic information regarding recurrence. |
format | Online Article Text |
id | pubmed-8947709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89477092022-03-25 FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma Jo, Joon-Hyung Chung, Hyun Woo So, Young Yoo, Young Bum Park, Kyoung Sik Nam, Sang Eun Lee, Eun Jeong Noh, Woo Chul Diagnostics (Basel) Article This study investigated the prognostic value of FDG PET/CT radiomic features for predicting recurrence in patients with early breast invasive ductal carcinoma (IDC). The medical records of consecutive patients who were newly diagnosed with primary breast IDC after curative surgery were reviewed. Patients who received any neoadjuvant treatment before surgery were not included. FDG PET/CT radiomic features, such as a maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), skewness, kurtosis, entropy, and uniformity, were measured for the primary breast tumor using LIFEx software to evaluate recurrence-free survival (RFS). A total of 124 patients with early breast IDC were evaluated. Eleven patients had a recurrence (8.9%). Univariate survival analysis identified large tumor size (>2 cm, p = 0.045), high Ki-67 expression (≥30%, p = 0.017), high AJCC prognostic stage (≥II, p = 0.044), high SUVmax (≥5.0, p = 0.002), high MTV (≥3.25 mL, p = 0.044), high TLG (≥10.5, p = 0.004), and high entropy (≥3.15, p = 0.003) as significant predictors of poor RFS. After multivariate survival analysis, only high MTV (p = 0.045) was an independent prognostic predictor. Evaluation of the MTV of the primary tumor by FDG PET/CT in patients with early breast IDC provides useful prognostic information regarding recurrence. MDPI 2022-03-12 /pmc/articles/PMC8947709/ /pubmed/35328247 http://dx.doi.org/10.3390/diagnostics12030694 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jo, Joon-Hyung Chung, Hyun Woo So, Young Yoo, Young Bum Park, Kyoung Sik Nam, Sang Eun Lee, Eun Jeong Noh, Woo Chul FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma |
title | FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma |
title_full | FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma |
title_fullStr | FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma |
title_full_unstemmed | FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma |
title_short | FDG PET/CT to Predict Recurrence of Early Breast Invasive Ductal Carcinoma |
title_sort | fdg pet/ct to predict recurrence of early breast invasive ductal carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947709/ https://www.ncbi.nlm.nih.gov/pubmed/35328247 http://dx.doi.org/10.3390/diagnostics12030694 |
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