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Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases

Mitochondrial dynamics encompass mitochondrial fusion, fission, and movement. Mitochondrial fission and fusion are seemingly ubiquitous, whereas mitochondrial movement is especially important for organelle transport through neuronal axons. Here, we review the roles of different mitochondrial dynamic...

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Detalles Bibliográficos
Autores principales: Dorn, Gerald W., Dang, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947719/
https://www.ncbi.nlm.nih.gov/pubmed/35326500
http://dx.doi.org/10.3390/cells11061049
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author Dorn, Gerald W.
Dang, Xiawei
author_facet Dorn, Gerald W.
Dang, Xiawei
author_sort Dorn, Gerald W.
collection PubMed
description Mitochondrial dynamics encompass mitochondrial fusion, fission, and movement. Mitochondrial fission and fusion are seemingly ubiquitous, whereas mitochondrial movement is especially important for organelle transport through neuronal axons. Here, we review the roles of different mitochondrial dynamic processes in mitochondrial quantity and quality control, emphasizing their impact on the neurological system in Charcot–Marie–Tooth disease type 2A, amyotrophic lateral sclerosis, Friedrich’s ataxia, dominant optic atrophy, and Alzheimer’s, Huntington’s, and Parkinson’s diseases. In addition to mechanisms and concepts, we explore in detail different technical approaches for measuring mitochondrial dynamic dysfunction in vitro, describe how results from tissue culture studies may be applied to a better understanding of mitochondrial dysdynamism in human neurodegenerative diseases, and suggest how this experimental platform can be used to evaluate candidate therapeutics in different diseases or in individual patients sharing the same clinical diagnosis.
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spelling pubmed-89477192022-03-25 Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases Dorn, Gerald W. Dang, Xiawei Cells Review Mitochondrial dynamics encompass mitochondrial fusion, fission, and movement. Mitochondrial fission and fusion are seemingly ubiquitous, whereas mitochondrial movement is especially important for organelle transport through neuronal axons. Here, we review the roles of different mitochondrial dynamic processes in mitochondrial quantity and quality control, emphasizing their impact on the neurological system in Charcot–Marie–Tooth disease type 2A, amyotrophic lateral sclerosis, Friedrich’s ataxia, dominant optic atrophy, and Alzheimer’s, Huntington’s, and Parkinson’s diseases. In addition to mechanisms and concepts, we explore in detail different technical approaches for measuring mitochondrial dynamic dysfunction in vitro, describe how results from tissue culture studies may be applied to a better understanding of mitochondrial dysdynamism in human neurodegenerative diseases, and suggest how this experimental platform can be used to evaluate candidate therapeutics in different diseases or in individual patients sharing the same clinical diagnosis. MDPI 2022-03-19 /pmc/articles/PMC8947719/ /pubmed/35326500 http://dx.doi.org/10.3390/cells11061049 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dorn, Gerald W.
Dang, Xiawei
Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases
title Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases
title_full Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases
title_fullStr Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases
title_full_unstemmed Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases
title_short Predicting Mitochondrial Dynamic Behavior in Genetically Defined Neurodegenerative Diseases
title_sort predicting mitochondrial dynamic behavior in genetically defined neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947719/
https://www.ncbi.nlm.nih.gov/pubmed/35326500
http://dx.doi.org/10.3390/cells11061049
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