Impact of CircRNAs on Ischemic Stroke

Circular RNA (circRNA) is a recently discovered class of endogenous non-coding RNA that is generated by cyclization, driven by intron pairing, and regulated by related regulators. An important biological function of CircRNA is acting as a molecular sponge to significantly alter miRNA levels over a s...

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Detalles Bibliográficos
Autores principales: Liu, Miaomiao, Liu, Xiaolin, Zhou, Maorong, Guo, Shao, Sun, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947829/
https://www.ncbi.nlm.nih.gov/pubmed/35371609
http://dx.doi.org/10.14336/AD.2021.1113
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author Liu, Miaomiao
Liu, Xiaolin
Zhou, Maorong
Guo, Shao
Sun, Kai
author_facet Liu, Miaomiao
Liu, Xiaolin
Zhou, Maorong
Guo, Shao
Sun, Kai
author_sort Liu, Miaomiao
collection PubMed
description Circular RNA (circRNA) is a recently discovered class of endogenous non-coding RNA that is generated by cyclization, driven by intron pairing, and regulated by related regulators. An important biological function of CircRNA is acting as a molecular sponge to significantly alter miRNA levels over a short period. Several studies have shown that circRNA is closely related to stroke. Therefore, a better understanding of CircRNA function and regulatory mechanism in ischemic brain will help us for the early detection, early diagnosis, and early treatment of stroke. Here, we summary the biological characteristics, expression of circRNA, and its effect on outcome after ischemic stroke.
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spelling pubmed-89478292022-04-01 Impact of CircRNAs on Ischemic Stroke Liu, Miaomiao Liu, Xiaolin Zhou, Maorong Guo, Shao Sun, Kai Aging Dis Commentary Circular RNA (circRNA) is a recently discovered class of endogenous non-coding RNA that is generated by cyclization, driven by intron pairing, and regulated by related regulators. An important biological function of CircRNA is acting as a molecular sponge to significantly alter miRNA levels over a short period. Several studies have shown that circRNA is closely related to stroke. Therefore, a better understanding of CircRNA function and regulatory mechanism in ischemic brain will help us for the early detection, early diagnosis, and early treatment of stroke. Here, we summary the biological characteristics, expression of circRNA, and its effect on outcome after ischemic stroke. JKL International LLC 2022-04-01 /pmc/articles/PMC8947829/ /pubmed/35371609 http://dx.doi.org/10.14336/AD.2021.1113 Text en Copyright: © 2022 Liu et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Commentary
Liu, Miaomiao
Liu, Xiaolin
Zhou, Maorong
Guo, Shao
Sun, Kai
Impact of CircRNAs on Ischemic Stroke
title Impact of CircRNAs on Ischemic Stroke
title_full Impact of CircRNAs on Ischemic Stroke
title_fullStr Impact of CircRNAs on Ischemic Stroke
title_full_unstemmed Impact of CircRNAs on Ischemic Stroke
title_short Impact of CircRNAs on Ischemic Stroke
title_sort impact of circrnas on ischemic stroke
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947829/
https://www.ncbi.nlm.nih.gov/pubmed/35371609
http://dx.doi.org/10.14336/AD.2021.1113
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