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DNA Methylation Modulates Aging Process in Adipocytes

Aging has been recognized to be a highly complex biological health problem with a high risk of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or emphysema, cancer and Alzheimer's disease. Particularly, age-related turnover in adipose tissue is a major contribut...

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Autores principales: Xie, Hao, Liu, Xin, Zhou, Qing, Huang, Teng, Zhang, Lu, Gao, Jia, Wang, Yuhan, Liu, Yanjun, Yan, Tong, Zhang, Shu, Wang, Cong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947842/
https://www.ncbi.nlm.nih.gov/pubmed/35371604
http://dx.doi.org/10.14336/AD.2021.0904
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author Xie, Hao
Liu, Xin
Zhou, Qing
Huang, Teng
Zhang, Lu
Gao, Jia
Wang, Yuhan
Liu, Yanjun
Yan, Tong
Zhang, Shu
Wang, Cong-Yi
author_facet Xie, Hao
Liu, Xin
Zhou, Qing
Huang, Teng
Zhang, Lu
Gao, Jia
Wang, Yuhan
Liu, Yanjun
Yan, Tong
Zhang, Shu
Wang, Cong-Yi
author_sort Xie, Hao
collection PubMed
description Aging has been recognized to be a highly complex biological health problem with a high risk of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or emphysema, cancer and Alzheimer's disease. Particularly, age-related turnover in adipose tissue is a major contributor to metabolic syndromes and shortened lifespan. Adipocytes undergo senescence in early stage, which results in adipose tissue metabolic dysfunction, redistribution, and inflammation. The well-established association between DNA methylation (DNAm) and aging has been observed in the past few decades. Indeed, age-related alteration in DNAm is highly tissue-specific. This review intends to summarize the advancements how DNAm changes coupled with aging process in adipose tissue, by which DNAm regulates cellular senescence, metabolic function, adipokine secretion and beiging process in adipocytes. Elucidation of the effect of DNAm on adipose aging would have great potential to the development of epigenetic therapeutic strategies against aging-related diseases in clinical settings.
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spelling pubmed-89478422022-04-01 DNA Methylation Modulates Aging Process in Adipocytes Xie, Hao Liu, Xin Zhou, Qing Huang, Teng Zhang, Lu Gao, Jia Wang, Yuhan Liu, Yanjun Yan, Tong Zhang, Shu Wang, Cong-Yi Aging Dis Review Aging has been recognized to be a highly complex biological health problem with a high risk of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or emphysema, cancer and Alzheimer's disease. Particularly, age-related turnover in adipose tissue is a major contributor to metabolic syndromes and shortened lifespan. Adipocytes undergo senescence in early stage, which results in adipose tissue metabolic dysfunction, redistribution, and inflammation. The well-established association between DNA methylation (DNAm) and aging has been observed in the past few decades. Indeed, age-related alteration in DNAm is highly tissue-specific. This review intends to summarize the advancements how DNAm changes coupled with aging process in adipose tissue, by which DNAm regulates cellular senescence, metabolic function, adipokine secretion and beiging process in adipocytes. Elucidation of the effect of DNAm on adipose aging would have great potential to the development of epigenetic therapeutic strategies against aging-related diseases in clinical settings. JKL International LLC 2022-04-01 /pmc/articles/PMC8947842/ /pubmed/35371604 http://dx.doi.org/10.14336/AD.2021.0904 Text en Copyright: © 2022 Xie et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Xie, Hao
Liu, Xin
Zhou, Qing
Huang, Teng
Zhang, Lu
Gao, Jia
Wang, Yuhan
Liu, Yanjun
Yan, Tong
Zhang, Shu
Wang, Cong-Yi
DNA Methylation Modulates Aging Process in Adipocytes
title DNA Methylation Modulates Aging Process in Adipocytes
title_full DNA Methylation Modulates Aging Process in Adipocytes
title_fullStr DNA Methylation Modulates Aging Process in Adipocytes
title_full_unstemmed DNA Methylation Modulates Aging Process in Adipocytes
title_short DNA Methylation Modulates Aging Process in Adipocytes
title_sort dna methylation modulates aging process in adipocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947842/
https://www.ncbi.nlm.nih.gov/pubmed/35371604
http://dx.doi.org/10.14336/AD.2021.0904
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