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Hypoxia Induces Apoptosis of Microglia BV2 by Upregulating Kir2.1 to Activate Mitochondrial-Related Apoptotic Pathways

AIM: To explore the role of Kir2.1 in hypoxia-induced microglial apoptosis. METHODS: BV2 microglial cell lines were cultured and treated with ML133 hydrochloride, a Kir2.1 channel blocker, for 23 h and with 500 μmol/L of CoCl(2) for 8 h. Cells were divided into the control, CoCl(2) (hypoxia-induced...

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Detalles Bibliográficos
Autores principales:	Xie, Yu-fang, Wang, Yan, Rong, Yi, He, Wenjun, Yan, Meijuan, Li, Xinzhi, Si, Junqiang, Li, Li, Zhang, Yingying, Ma, Ketao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947871/ https://www.ncbi.nlm.nih.gov/pubmed/35340413 http://dx.doi.org/10.1155/2022/5855889

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