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Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection
Haemophilus influenzae (H. influenzae) is a facultative anaerobe, pleomorphic Gram-negative coccobacillus capable of causing various respiratory and blood stream infections. Introduction of childhood immunization against H. influenza type b has decreased its prevalence. Invasive infection with non-t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947951/ https://www.ncbi.nlm.nih.gov/pubmed/35371694 http://dx.doi.org/10.7759/cureus.22424 |
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author | Walls, Sheri Adhikari, Prakash Reesha, Hawwa Baxter, Martin |
author_facet | Walls, Sheri Adhikari, Prakash Reesha, Hawwa Baxter, Martin |
author_sort | Walls, Sheri |
collection | PubMed |
description | Haemophilus influenzae (H. influenzae) is a facultative anaerobe, pleomorphic Gram-negative coccobacillus capable of causing various respiratory and blood stream infections. Introduction of childhood immunization against H. influenza type b has decreased its prevalence. Invasive infection with non-typeable H. influenzae is increasing specially in vulnerable population. We present a case of a 69-year-old female who developed septic shock due to H. influenzae infection. She was also found to have influenza A infection in bronchoalveolar lavage (BAL) sample although initial test with nasopharyngeal swab was negative. This case report highlights the fact that in patients with high clinical suspicion, negative nasopharyngeal swab with polymerase chain reaction may not rule out influenza infection and BAL may be necessary to confirm the diagnosis and H. influenzae can be causing bacterial superinfection in such patients. She was appropriately treated with third-generation cephalosporin for H. influenzae and with oseltamivir for influenza A. Her condition improved significantly with the treatment. |
format | Online Article Text |
id | pubmed-8947951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-89479512022-04-01 Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection Walls, Sheri Adhikari, Prakash Reesha, Hawwa Baxter, Martin Cureus Internal Medicine Haemophilus influenzae (H. influenzae) is a facultative anaerobe, pleomorphic Gram-negative coccobacillus capable of causing various respiratory and blood stream infections. Introduction of childhood immunization against H. influenza type b has decreased its prevalence. Invasive infection with non-typeable H. influenzae is increasing specially in vulnerable population. We present a case of a 69-year-old female who developed septic shock due to H. influenzae infection. She was also found to have influenza A infection in bronchoalveolar lavage (BAL) sample although initial test with nasopharyngeal swab was negative. This case report highlights the fact that in patients with high clinical suspicion, negative nasopharyngeal swab with polymerase chain reaction may not rule out influenza infection and BAL may be necessary to confirm the diagnosis and H. influenzae can be causing bacterial superinfection in such patients. She was appropriately treated with third-generation cephalosporin for H. influenzae and with oseltamivir for influenza A. Her condition improved significantly with the treatment. Cureus 2022-02-21 /pmc/articles/PMC8947951/ /pubmed/35371694 http://dx.doi.org/10.7759/cureus.22424 Text en Copyright © 2022, Walls et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Walls, Sheri Adhikari, Prakash Reesha, Hawwa Baxter, Martin Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection |
title | Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection |
title_full | Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection |
title_fullStr | Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection |
title_full_unstemmed | Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection |
title_short | Sepsis Due to Haemophilus influenzae and Masked Influenza A Infection |
title_sort | sepsis due to haemophilus influenzae and masked influenza a infection |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947951/ https://www.ncbi.nlm.nih.gov/pubmed/35371694 http://dx.doi.org/10.7759/cureus.22424 |
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