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Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa

BACKGROUND: Under the Global Programme to Eliminate Lymphatic Filariasis (LF), American Samoa conducted 7 rounds of mass drug administration (MDA) between 2000 and 2006. The territory passed transmission assessment surveys (TASs) in 2011 (TAS-1) and 2015 (TAS-2). In 2016, the territory failed TAS-3,...

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Main Authors: Cadavid Restrepo, Angela M., Gass, Katherine, Won, Kimberly Y., Sheel, Meru, Robinson, Keri, Graves, Patricia M., Fuimaono, Saipale, Lau, Colleen L
Format: Online Article Text
Language:English
Published: Elsevier 2022
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948089/
https://www.ncbi.nlm.nih.gov/pubmed/35150913
http://dx.doi.org/10.1016/j.ijid.2022.02.006
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author Cadavid Restrepo, Angela M.
Gass, Katherine
Won, Kimberly Y.
Sheel, Meru
Robinson, Keri
Graves, Patricia M.
Fuimaono, Saipale
Lau, Colleen L
author_facet Cadavid Restrepo, Angela M.
Gass, Katherine
Won, Kimberly Y.
Sheel, Meru
Robinson, Keri
Graves, Patricia M.
Fuimaono, Saipale
Lau, Colleen L
author_sort Cadavid Restrepo, Angela M.
collection PubMed
description BACKGROUND: Under the Global Programme to Eliminate Lymphatic Filariasis (LF), American Samoa conducted 7 rounds of mass drug administration (MDA) between 2000 and 2006. The territory passed transmission assessment surveys (TASs) in 2011 (TAS-1) and 2015 (TAS-2). In 2016, the territory failed TAS-3, indicating resurgence. This study aims to determine if antibodies (Abs) may have provided a timelier indication of LF resurgence in American Samoa. METHODS: We examined school-level antigen (Ag) and Ab status (presence/absence of Ag- and Ab-positive children) and prevalence of single and combined Ab responses to Wb123, Bm14, and Bm33 Ags at each TAS. Pearson chi-square test and logistic regression were used to examine associations between school-level Ab prevalence in TAS-1 and TAS-2 and school-level Ag status in TAS-3. RESULTS: Schools with higher prevalence of Wb123 Ab in TAS-2 had higher odds of being Ag-positive in TAS-3 (odds ratio [OR] 24.5, 95% confidence interval [CI] 1.2–512.7). Schools that were Ab-positive for WB123 plus Bm14, Bm33, or both Bm14 and Bm33 in TAS-2 had higher odds of being Ag-positive in TAS-3 (OR 16.0–24.5). CONCLUSION: Abs could provide earlier signals of resurgence and enable a timelier response. The promising role of Abs in surveillance after MDA and decision making should be further investigated in other settings.
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spelling pubmed-89480892022-04-01 Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa Cadavid Restrepo, Angela M. Gass, Katherine Won, Kimberly Y. Sheel, Meru Robinson, Keri Graves, Patricia M. Fuimaono, Saipale Lau, Colleen L Int J Infect Dis Article BACKGROUND: Under the Global Programme to Eliminate Lymphatic Filariasis (LF), American Samoa conducted 7 rounds of mass drug administration (MDA) between 2000 and 2006. The territory passed transmission assessment surveys (TASs) in 2011 (TAS-1) and 2015 (TAS-2). In 2016, the territory failed TAS-3, indicating resurgence. This study aims to determine if antibodies (Abs) may have provided a timelier indication of LF resurgence in American Samoa. METHODS: We examined school-level antigen (Ag) and Ab status (presence/absence of Ag- and Ab-positive children) and prevalence of single and combined Ab responses to Wb123, Bm14, and Bm33 Ags at each TAS. Pearson chi-square test and logistic regression were used to examine associations between school-level Ab prevalence in TAS-1 and TAS-2 and school-level Ag status in TAS-3. RESULTS: Schools with higher prevalence of Wb123 Ab in TAS-2 had higher odds of being Ag-positive in TAS-3 (odds ratio [OR] 24.5, 95% confidence interval [CI] 1.2–512.7). Schools that were Ab-positive for WB123 plus Bm14, Bm33, or both Bm14 and Bm33 in TAS-2 had higher odds of being Ag-positive in TAS-3 (OR 16.0–24.5). CONCLUSION: Abs could provide earlier signals of resurgence and enable a timelier response. The promising role of Abs in surveillance after MDA and decision making should be further investigated in other settings. Elsevier 2022-04 /pmc/articles/PMC8948089/ /pubmed/35150913 http://dx.doi.org/10.1016/j.ijid.2022.02.006 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cadavid Restrepo, Angela M.
Gass, Katherine
Won, Kimberly Y.
Sheel, Meru
Robinson, Keri
Graves, Patricia M.
Fuimaono, Saipale
Lau, Colleen L
Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa
title Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa
title_full Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa
title_fullStr Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa
title_full_unstemmed Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa
title_short Potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in American Samoa
title_sort potential use of antibodies to provide an earlier indication of lymphatic filariasis resurgence in post–mass drug ad ministration surveillance in american samoa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948089/
https://www.ncbi.nlm.nih.gov/pubmed/35150913
http://dx.doi.org/10.1016/j.ijid.2022.02.006
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