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Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay

The unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum (ER). Residing in the ER membrane, the UPR mediator Ire1 deploys its cytoplasmic kinase-endoribonuclease domain to activate the key UPR transcription factor Xbp1 through non-conventional splicing of Xbp1 mRNA. Ire...

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Detalles Bibliográficos
Autores principales:	Cairrão, Fátima, Santos, Cristiana C., Le Thomas, Adrien, Marsters, Scot, Ashkenazi, Avi, Domingos, Pedro M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948244/ https://www.ncbi.nlm.nih.gov/pubmed/35332141 http://dx.doi.org/10.1038/s41467-022-29105-x

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