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The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro

Non-T2 severe asthma and chronic obstructive pulmonary disease (COPD) are airway chronic inflammatory disorders with a poor response to corticosteroids. LAS194046, a novel pan-Janus kinase (JAK) inhibitor, shows inhibitory effects on T2 allergic lung inflammation in rats. In this work we analyze the...

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Detalles Bibliográficos
Autores principales:	Milara, Javier, Ballester, Beatriz, de Diego, Alfredo, Calbet, Marta, Ramis, Isabel, Miralpeix, Montserrat, Cortijo, Julio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948298/ https://www.ncbi.nlm.nih.gov/pubmed/35332239 http://dx.doi.org/10.1038/s41598-022-09241-6

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