Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease

Although mature podocytes lack tight junctions, tight junction integral membrane protein claudin-5 (CLDN5) is predominantly expressed on plasma membranes of podocytes under normal conditions. Using podocyte-specific Cldn5 knockout mice, we identify CLDN5 as a crucial regulator of podocyte function a...

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Detalles Bibliográficos
Autores principales: Sun, Hui, Li, Hui, Yan, Jie, Wang, Xiangdong, Xu, Mengyuan, Wang, Mingxia, Fan, Baozhen, Liu, Jieying, Lin, Ninghua, Wang, Xin, Li, Li, Zhao, Shengtian, Gong, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948304/
https://www.ncbi.nlm.nih.gov/pubmed/35332151
http://dx.doi.org/10.1038/s41467-022-29277-6

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