Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
BACKGROUND: Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments i...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948321/ https://www.ncbi.nlm.nih.gov/pubmed/35341227 http://dx.doi.org/10.1177/09727531211046367 |
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author | Miranpuri, Gurwattan S. Bali, Parul Nguyen, Justyn Kim, Jason J Modgil, Shweta Mehra, Priya Buttar, Seah Brown, Greta Yutuc, Noemi Singh, Harpreet Wood, Aleksandar Singh, Jagtar Anand, Akshay |
author_facet | Miranpuri, Gurwattan S. Bali, Parul Nguyen, Justyn Kim, Jason J Modgil, Shweta Mehra, Priya Buttar, Seah Brown, Greta Yutuc, Noemi Singh, Harpreet Wood, Aleksandar Singh, Jagtar Anand, Akshay |
author_sort | Miranpuri, Gurwattan S. |
collection | PubMed |
description | BACKGROUND: Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments in treating NP because there is a lack of understanding regarding the mechanisms behind SCI-induced NP (SCINP). Given that more than 450,000 people in the United States alone suffer from SCI, it is unsatisfactory that current treatments yield poor results in alleviating and treating NP. SUMMARY: In this review, we briefly discussed the models of SCINP along with the mechanisms of NP progression. Further, current treatment modalities are herein explored for SCINP involving pharmacological interventions targeting glia cells and astrocytes. KEY MESSAGE: The studies presented in this review provide insight for new directions regarding SCINP alleviation. Given the severity and incapacitating effects of SCINP, it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment. |
format | Online Article Text |
id | pubmed-8948321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-89483212022-03-26 Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain Miranpuri, Gurwattan S. Bali, Parul Nguyen, Justyn Kim, Jason J Modgil, Shweta Mehra, Priya Buttar, Seah Brown, Greta Yutuc, Noemi Singh, Harpreet Wood, Aleksandar Singh, Jagtar Anand, Akshay Ann Neurosci Review Articles BACKGROUND: Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments in treating NP because there is a lack of understanding regarding the mechanisms behind SCI-induced NP (SCINP). Given that more than 450,000 people in the United States alone suffer from SCI, it is unsatisfactory that current treatments yield poor results in alleviating and treating NP. SUMMARY: In this review, we briefly discussed the models of SCINP along with the mechanisms of NP progression. Further, current treatment modalities are herein explored for SCINP involving pharmacological interventions targeting glia cells and astrocytes. KEY MESSAGE: The studies presented in this review provide insight for new directions regarding SCINP alleviation. Given the severity and incapacitating effects of SCINP, it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment. SAGE Publications 2021-10-18 2021-07 /pmc/articles/PMC8948321/ /pubmed/35341227 http://dx.doi.org/10.1177/09727531211046367 Text en © 2021 Indian Academy of Neurosciences (IAN) https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Articles Miranpuri, Gurwattan S. Bali, Parul Nguyen, Justyn Kim, Jason J Modgil, Shweta Mehra, Priya Buttar, Seah Brown, Greta Yutuc, Noemi Singh, Harpreet Wood, Aleksandar Singh, Jagtar Anand, Akshay Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain |
title | Role of Microglia and Astrocytes in Spinal Cord Injury Induced
Neuropathic Pain |
title_full | Role of Microglia and Astrocytes in Spinal Cord Injury Induced
Neuropathic Pain |
title_fullStr | Role of Microglia and Astrocytes in Spinal Cord Injury Induced
Neuropathic Pain |
title_full_unstemmed | Role of Microglia and Astrocytes in Spinal Cord Injury Induced
Neuropathic Pain |
title_short | Role of Microglia and Astrocytes in Spinal Cord Injury Induced
Neuropathic Pain |
title_sort | role of microglia and astrocytes in spinal cord injury induced
neuropathic pain |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948321/ https://www.ncbi.nlm.nih.gov/pubmed/35341227 http://dx.doi.org/10.1177/09727531211046367 |
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