Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain

BACKGROUND: Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments i...

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Autores principales: Miranpuri, Gurwattan S., Bali, Parul, Nguyen, Justyn, Kim, Jason J, Modgil, Shweta, Mehra, Priya, Buttar, Seah, Brown, Greta, Yutuc, Noemi, Singh, Harpreet, Wood, Aleksandar, Singh, Jagtar, Anand, Akshay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948321/
https://www.ncbi.nlm.nih.gov/pubmed/35341227
http://dx.doi.org/10.1177/09727531211046367
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author Miranpuri, Gurwattan S.
Bali, Parul
Nguyen, Justyn
Kim, Jason J
Modgil, Shweta
Mehra, Priya
Buttar, Seah
Brown, Greta
Yutuc, Noemi
Singh, Harpreet
Wood, Aleksandar
Singh, Jagtar
Anand, Akshay
author_facet Miranpuri, Gurwattan S.
Bali, Parul
Nguyen, Justyn
Kim, Jason J
Modgil, Shweta
Mehra, Priya
Buttar, Seah
Brown, Greta
Yutuc, Noemi
Singh, Harpreet
Wood, Aleksandar
Singh, Jagtar
Anand, Akshay
author_sort Miranpuri, Gurwattan S.
collection PubMed
description BACKGROUND: Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments in treating NP because there is a lack of understanding regarding the mechanisms behind SCI-induced NP (SCINP). Given that more than 450,000 people in the United States alone suffer from SCI, it is unsatisfactory that current treatments yield poor results in alleviating and treating NP. SUMMARY: In this review, we briefly discussed the models of SCINP along with the mechanisms of NP progression. Further, current treatment modalities are herein explored for SCINP involving pharmacological interventions targeting glia cells and astrocytes. KEY MESSAGE: The studies presented in this review provide insight for new directions regarding SCINP alleviation. Given the severity and incapacitating effects of SCINP, it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment.
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spelling pubmed-89483212022-03-26 Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain Miranpuri, Gurwattan S. Bali, Parul Nguyen, Justyn Kim, Jason J Modgil, Shweta Mehra, Priya Buttar, Seah Brown, Greta Yutuc, Noemi Singh, Harpreet Wood, Aleksandar Singh, Jagtar Anand, Akshay Ann Neurosci Review Articles BACKGROUND: Spinal cord injuries incite varying degrees of symptoms in patients, ranging from weakness and incoordination to paralysis. Common amongst spinal cord injury (SCI) patients, neuropathic pain (NP) is a debilitating medical condition. Unfortunately, there remain many clinical impediments in treating NP because there is a lack of understanding regarding the mechanisms behind SCI-induced NP (SCINP). Given that more than 450,000 people in the United States alone suffer from SCI, it is unsatisfactory that current treatments yield poor results in alleviating and treating NP. SUMMARY: In this review, we briefly discussed the models of SCINP along with the mechanisms of NP progression. Further, current treatment modalities are herein explored for SCINP involving pharmacological interventions targeting glia cells and astrocytes. KEY MESSAGE: The studies presented in this review provide insight for new directions regarding SCINP alleviation. Given the severity and incapacitating effects of SCINP, it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment. SAGE Publications 2021-10-18 2021-07 /pmc/articles/PMC8948321/ /pubmed/35341227 http://dx.doi.org/10.1177/09727531211046367 Text en © 2021 Indian Academy of Neurosciences (IAN) https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Articles
Miranpuri, Gurwattan S.
Bali, Parul
Nguyen, Justyn
Kim, Jason J
Modgil, Shweta
Mehra, Priya
Buttar, Seah
Brown, Greta
Yutuc, Noemi
Singh, Harpreet
Wood, Aleksandar
Singh, Jagtar
Anand, Akshay
Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
title Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
title_full Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
title_fullStr Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
title_full_unstemmed Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
title_short Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain
title_sort role of microglia and astrocytes in spinal cord injury induced neuropathic pain
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948321/
https://www.ncbi.nlm.nih.gov/pubmed/35341227
http://dx.doi.org/10.1177/09727531211046367
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