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Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model
The cerebral cortex performs its computations with many six-layered fundamental units, collectively spreading along the cortical sheet. What is the local network structure and the operating dynamics of such a fundamental unit? Previous investigations of primary sensory areas revealed a classic “cano...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japan Academy
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948418/ https://www.ncbi.nlm.nih.gov/pubmed/35283409 http://dx.doi.org/10.2183/pjab.98.007 |
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author | MIYASHITA, Yasushi |
author_facet | MIYASHITA, Yasushi |
author_sort | MIYASHITA, Yasushi |
collection | PubMed |
description | The cerebral cortex performs its computations with many six-layered fundamental units, collectively spreading along the cortical sheet. What is the local network structure and the operating dynamics of such a fundamental unit? Previous investigations of primary sensory areas revealed a classic “canonical” circuit model, leading to an expectation of similar circuit organization and dynamics throughout the cortex. This review clarifies the different circuit dynamics at play in the higher association cortex of primates that implements computation for high-level cognition such as memory and attention. Instead of feedforward processing of response selectivity through Layers 4 to 2/3 that the classic canonical circuit stipulates, memory recall in primates occurs in Layer 5/6 with local backward projection to Layer 2/3, after which the retrieved information is sent back from Layer 6 to lower-level cortical areas for further retrieval of nested associations of target attributes. In this review, a novel “dynamic multimode module (D3M)” in the primate association cortex is proposed, as a new “canonical” circuit model performing this operation. |
format | Online Article Text |
id | pubmed-8948418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japan Academy |
record_format | MEDLINE/PubMed |
spelling | pubmed-89484182022-03-31 Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model MIYASHITA, Yasushi Proc Jpn Acad Ser B Phys Biol Sci Review The cerebral cortex performs its computations with many six-layered fundamental units, collectively spreading along the cortical sheet. What is the local network structure and the operating dynamics of such a fundamental unit? Previous investigations of primary sensory areas revealed a classic “canonical” circuit model, leading to an expectation of similar circuit organization and dynamics throughout the cortex. This review clarifies the different circuit dynamics at play in the higher association cortex of primates that implements computation for high-level cognition such as memory and attention. Instead of feedforward processing of response selectivity through Layers 4 to 2/3 that the classic canonical circuit stipulates, memory recall in primates occurs in Layer 5/6 with local backward projection to Layer 2/3, after which the retrieved information is sent back from Layer 6 to lower-level cortical areas for further retrieval of nested associations of target attributes. In this review, a novel “dynamic multimode module (D3M)” in the primate association cortex is proposed, as a new “canonical” circuit model performing this operation. The Japan Academy 2022-03-11 /pmc/articles/PMC8948418/ /pubmed/35283409 http://dx.doi.org/10.2183/pjab.98.007 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by-nc/4.0/Published under the terms of the CC BY-NC license https://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review MIYASHITA, Yasushi Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
title | Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
title_full | Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
title_fullStr | Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
title_full_unstemmed | Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
title_short | Operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
title_sort | operating principles of the cerebral cortex as a six-layered network in primates: beyond the classic canonical circuit model |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948418/ https://www.ncbi.nlm.nih.gov/pubmed/35283409 http://dx.doi.org/10.2183/pjab.98.007 |
work_keys_str_mv | AT miyashitayasushi operatingprinciplesofthecerebralcortexasasixlayerednetworkinprimatesbeyondtheclassiccanonicalcircuitmodel |