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Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans
Many organisms can survive and proliferate in changing environmental temperatures. Here, we introduce a molecular physiological mechanism for cold tolerance and acclimation of the nematode Caenorhabditis elegans on the basis of previous reports and a new result. Three types of thermosensory neurons...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japan Academy
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948419/ https://www.ncbi.nlm.nih.gov/pubmed/35283408 http://dx.doi.org/10.2183/pjab.98.009 |
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author | OKAHATA, Misaki MOTOMURA, Haruka OHTA, Akane KUHARA, Atsushi |
author_facet | OKAHATA, Misaki MOTOMURA, Haruka OHTA, Akane KUHARA, Atsushi |
author_sort | OKAHATA, Misaki |
collection | PubMed |
description | Many organisms can survive and proliferate in changing environmental temperatures. Here, we introduce a molecular physiological mechanism for cold tolerance and acclimation of the nematode Caenorhabditis elegans on the basis of previous reports and a new result. Three types of thermosensory neurons located in the head, ASJ, ASG, and ADL, regulate cold tolerance and acclimation. In ASJ, components of the light-signaling pathway are involved in thermosensation. In ASG, mechanoreceptor DEG-1 acts as thermoreceptor. In ADL, transient receptor potential channels are thermoreceptors; however, the presence of an additional unidentified thermoreceptor is also speculated. ADL thermoresponsivity is modulated by oxygen sensory signaling from URX oxygen sensory neurons via hub interneurons. ASJ releases insulin and steroid hormones that are received by the intestine, which results in lipid composition changing with cold tolerance. Additionally, the intestinal transcriptional alteration affects sperm functions, which in turn affects the thermosensitivity of ASJ; thus, the neuron–intestine–sperm–neuron tissue circuit is essential for cold tolerance. |
format | Online Article Text |
id | pubmed-8948419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japan Academy |
record_format | MEDLINE/PubMed |
spelling | pubmed-89484192022-03-31 Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans OKAHATA, Misaki MOTOMURA, Haruka OHTA, Akane KUHARA, Atsushi Proc Jpn Acad Ser B Phys Biol Sci Review Many organisms can survive and proliferate in changing environmental temperatures. Here, we introduce a molecular physiological mechanism for cold tolerance and acclimation of the nematode Caenorhabditis elegans on the basis of previous reports and a new result. Three types of thermosensory neurons located in the head, ASJ, ASG, and ADL, regulate cold tolerance and acclimation. In ASJ, components of the light-signaling pathway are involved in thermosensation. In ASG, mechanoreceptor DEG-1 acts as thermoreceptor. In ADL, transient receptor potential channels are thermoreceptors; however, the presence of an additional unidentified thermoreceptor is also speculated. ADL thermoresponsivity is modulated by oxygen sensory signaling from URX oxygen sensory neurons via hub interneurons. ASJ releases insulin and steroid hormones that are received by the intestine, which results in lipid composition changing with cold tolerance. Additionally, the intestinal transcriptional alteration affects sperm functions, which in turn affects the thermosensitivity of ASJ; thus, the neuron–intestine–sperm–neuron tissue circuit is essential for cold tolerance. The Japan Academy 2022-03-11 /pmc/articles/PMC8948419/ /pubmed/35283408 http://dx.doi.org/10.2183/pjab.98.009 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by-nc/4.0/Published under the terms of the CC BY-NC license https://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review OKAHATA, Misaki MOTOMURA, Haruka OHTA, Akane KUHARA, Atsushi Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans |
title | Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans |
title_full | Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans |
title_fullStr | Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans |
title_full_unstemmed | Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans |
title_short | Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans |
title_sort | molecular physiology regulating cold tolerance and acclimation of caenorhabditis elegans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948419/ https://www.ncbi.nlm.nih.gov/pubmed/35283408 http://dx.doi.org/10.2183/pjab.98.009 |
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