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Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study

OBJECTIVES: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and mortality at a 5-year follow-up. METHODS: Prevalent atherosclerosis was assesse...

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Autores principales: Nawaz, Beenish, Fromm, Annette, Øygarden, Halvor, Eide, Geir E, Saeed, Sahrai, Meijer, Rudy, Bots, Michiel L, Sand, Kristin M, Thomassen, Lars, Næss, Halvor, Waje-Andreassen, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948509/
https://www.ncbi.nlm.nih.gov/pubmed/35342817
http://dx.doi.org/10.1177/23969873211059472
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author Nawaz, Beenish
Fromm, Annette
Øygarden, Halvor
Eide, Geir E
Saeed, Sahrai
Meijer, Rudy
Bots, Michiel L
Sand, Kristin M
Thomassen, Lars
Næss, Halvor
Waje-Andreassen, Ulrike
author_facet Nawaz, Beenish
Fromm, Annette
Øygarden, Halvor
Eide, Geir E
Saeed, Sahrai
Meijer, Rudy
Bots, Michiel L
Sand, Kristin M
Thomassen, Lars
Næss, Halvor
Waje-Andreassen, Ulrike
author_sort Nawaz, Beenish
collection PubMed
description OBJECTIVES: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and mortality at a 5-year follow-up. METHODS: Prevalent atherosclerosis was assessed for 385 patients and 260 controls in seven vascular areas by electrocardiogram (ECG), ankle–arm index (AAI) and measurement of right and left carotid and femoral intima-media thickness (cIMT and fIMT) and abdominal aorta plaques (AAP). Clinical end-points were any new CVE (stroke, angina, myocardial infarction or peripheral arterial disease) or death from any cause at 5-year follow-up. All results were sex- and age-adjusted; logistic regression and Cox proportional hazards models were applied. RESULTS: Young patients ≤49 years had prevalent atherosclerosis in 1/2 of males and 1/3 of females. Compared with controls, young female patients showed significantly higher prevalent atherosclerosis, p = 0.024. Ischaemic ECG and mean cIMT were higher in young and middle-aged female patients (p = 0.044, p = 0.020, p = 0.023 and p <0.001, respectively). Mean fIMT was higher in middle-aged female patients (p <0.001). Cardiovascular events were associated with ischaemic ECG; AAI ≤0.9, fIMT ≥0.9 mm and increased number of areas with atherosclerosis (NAA) among patients, and with AAP, cIMT ≥0.9 mm, fIMT ≥0.9 mm and NAA among controls. Mortality was associated with higher age, ischaemic ECG and NAA among patients, and cIMT ≥0.9 mm among controls. CONCLUSION: Atherosclerosis is highly prevalent even in young stroke patients. Some areas and increasing NAA are associated with CVEs and death.
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spelling pubmed-89485092022-03-26 Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study Nawaz, Beenish Fromm, Annette Øygarden, Halvor Eide, Geir E Saeed, Sahrai Meijer, Rudy Bots, Michiel L Sand, Kristin M Thomassen, Lars Næss, Halvor Waje-Andreassen, Ulrike Eur Stroke J Original Research Articles OBJECTIVES: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and mortality at a 5-year follow-up. METHODS: Prevalent atherosclerosis was assessed for 385 patients and 260 controls in seven vascular areas by electrocardiogram (ECG), ankle–arm index (AAI) and measurement of right and left carotid and femoral intima-media thickness (cIMT and fIMT) and abdominal aorta plaques (AAP). Clinical end-points were any new CVE (stroke, angina, myocardial infarction or peripheral arterial disease) or death from any cause at 5-year follow-up. All results were sex- and age-adjusted; logistic regression and Cox proportional hazards models were applied. RESULTS: Young patients ≤49 years had prevalent atherosclerosis in 1/2 of males and 1/3 of females. Compared with controls, young female patients showed significantly higher prevalent atherosclerosis, p = 0.024. Ischaemic ECG and mean cIMT were higher in young and middle-aged female patients (p = 0.044, p = 0.020, p = 0.023 and p <0.001, respectively). Mean fIMT was higher in middle-aged female patients (p <0.001). Cardiovascular events were associated with ischaemic ECG; AAI ≤0.9, fIMT ≥0.9 mm and increased number of areas with atherosclerosis (NAA) among patients, and with AAP, cIMT ≥0.9 mm, fIMT ≥0.9 mm and NAA among controls. Mortality was associated with higher age, ischaemic ECG and NAA among patients, and cIMT ≥0.9 mm among controls. CONCLUSION: Atherosclerosis is highly prevalent even in young stroke patients. Some areas and increasing NAA are associated with CVEs and death. SAGE Publications 2021-11-11 2021-12 /pmc/articles/PMC8948509/ /pubmed/35342817 http://dx.doi.org/10.1177/23969873211059472 Text en © European Stroke Organisation 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Articles
Nawaz, Beenish
Fromm, Annette
Øygarden, Halvor
Eide, Geir E
Saeed, Sahrai
Meijer, Rudy
Bots, Michiel L
Sand, Kristin M
Thomassen, Lars
Næss, Halvor
Waje-Andreassen, Ulrike
Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
title Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
title_full Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
title_fullStr Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
title_full_unstemmed Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
title_short Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
title_sort prevalence of atherosclerosis and association with 5-year outcome: the norwegian stroke in the young study
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948509/
https://www.ncbi.nlm.nih.gov/pubmed/35342817
http://dx.doi.org/10.1177/23969873211059472
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