An RNA Interference/Adeno‐Associated Virus Vector–Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus

Hepatitis E virus (HEV) is a major public health problem with limited therapeutic options. Here, we engineered adeno‐associated viral vectors of serotype 6 (AAV6) to express short hairpin RNAs (shRNAs) against HEV transcripts with the prospect of down‐regulating HEV replication in vivo. We designed...

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Detalles Bibliográficos
Autores principales: Zhang, Cindy, Freistaedter, Andrew, Schmelas, Carolin, Gunkel, Manuel, Dao Thi, Viet Loan, Grimm, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948557/
https://www.ncbi.nlm.nih.gov/pubmed/34719133
http://dx.doi.org/10.1002/hep4.1842

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