Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways

Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, and have achieved remarkable success in the treatment of patients with refractory leukemia and lymphoma. However, dysfunction of T cells, including exhaustion, is an inevitable obstacle for persistent c...

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Detalles Bibliográficos
Autores principales: Shao, Mi, Teng, Xinyi, Guo, Xin, Zhang, Hao, Huang, Yue, Cui, Jiazhen, Si, Xiaohui, Ding, Lijuan, Wang, Xiujian, Li, Xia, Shi, Jimin, Zhang, Mingming, Kong, Delin, Gu, Tianning, Hu, Yongxian, Qian, Pengxu, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948559/
https://www.ncbi.nlm.nih.gov/pubmed/35032108
http://dx.doi.org/10.1002/advs.202103508

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