Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol

Proprotein convertase subtilisin/kexin type 9 (Pcsk9) binds to hepatic low‐density lipoprotein receptor (LDLR) and induces its internalization and degradation. Pcsk9 inhibition increases LDLR expression by hepatocytes, which causes increased uptake of circulating LDL, thereby reducing plasma LDL‐cho...

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Detalles Bibliográficos
Autores principales: Ioannou, George N., Lee, Sum P., Linsley, Peter S., Gersuk, Vivian, Yeh, Matthew M., Chen, Yen‐Ying, Peng, Yi‐Jen, Dutta, Moumita, Mascarinas, Gabby, Molla, Bruk, Cui, Julia Yue, Savard, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948564/
https://www.ncbi.nlm.nih.gov/pubmed/34816633
http://dx.doi.org/10.1002/hep4.1858

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