A Negative Feedback Loop and Transcription Factor Cooperation Regulate Zonal Gene Induction by 2, 3, 7, 8‐Tetrachlorodibenzo‐p‐Dioxin in the Mouse Liver

The cytochrome P450 (Cyp) proteins Cyp1A1 and Cyp1A2 are strongly induced in the mouse liver by the potent environmental toxicant 2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin (TCDD), acting through the aryl hydrocarbon receptor (AHR). The induction of Cyp1A1 is localized within the centrilobular regions o...

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Detalles Bibliográficos
Autores principales: Yang, Yongliang, Filipovic, David, Bhattacharya, Sudin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948569/
https://www.ncbi.nlm.nih.gov/pubmed/34726355
http://dx.doi.org/10.1002/hep4.1848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948569/
https://www.ncbi.nlm.nih.gov/pubmed/34726355
http://dx.doi.org/10.1002/hep4.1848

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